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Organic compounds that consists entirely of hydrogen and carbon elements usually organized in a chain; some may have a cyclic structure. Includes hydrocarbons that have additional functional groups such as aromatic rings.
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Cycloheptane-1,3-dione (Compound 1A) is an intermediate that can be used to synthesize Compound 1-1, which exhibits anticancer activity against colon cancer.
Molecular weight: 126.16
Formula: C7H10O2
Appearance: Liquid
Color: Colorless to light yellow
Density: 1.1 g/cm3
Purity: 99.73%
Solubility in DMSO: ≥ 100 mg/mL (792.64 mM)
Product format: 10 mM in 1 mL of DMSO
Shipping: Room temperature in continental US
Storage (pure form): -20°C for 3 years; 4°C for 2 years
Storage (in solvent): -80°C for 6 months; -20°C for 1 month
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A hydroxy fatty acid and an active metabolite of 9-PAHSA; inhibits HDAC1 in HT-29 cell lysates at 5 µM; inhibits proliferation of, and induces cell cycle arrest at the G0/G1 phase in, HT-29 cells at 100 µM
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A long-chain saturated fatty acid; a major component of cocoa butter and has also been found in beef fat and vegetable oils; does not induce hypercholesterolemia or raise LDL-cholesterol unlike many long-chain saturated fatty acids
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Octadecane-1-thiol-d37 is the deuterium labeled Octadecane-1-thiol. It is for research use only and not sold to patients.
Can be used as a tracer.
Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
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A hydroxy fatty acid; a low molecular weight gelator that self-assembles to form organogels; administration of paclitaxel in 12-hydroxy stearic acid-containing gel nanocarriers enhances tumor growth suppression in an H22 murine hepatocellular carcinoma model
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TPI-287 is a blood-brain barrier-permeable microtubule stabilizer that can significantly reduce metastatic colonization of breast cancer in the brain. It has been shown to effectively reduce tumor volume and inhibit tumor growth in mouse tumor models.
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Dynole 2-24 is an indole-based dynamin GTPase inhibitor with an IC50 of 0.56 μM for dynamin I. It is nontoxic and demonstrates increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). The product also exhibits 4.4-fold selectivity for dynamin I and is an active in-cell inhibitor of clathrin-mediated endocytosis (CME).
Indole-based dynamin GTPase inhibitor
Nontoxic
Increased potency against dynamin I and II in vitro and in cells
4.4-fold selectivity for dynamin I
Active in-cell inhibitor of clathrin-mediated endocytosis (CME)
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TPI-287 is a blood-brain barrier-permeable microtubule stabilizer that can significantly reduce metastatic colonization of breast cancer in the brain. This product is for research use only.
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N-Heptadecane is a straight-chain saturated hydrocarbon used as a technical reagent and analytical standard. It serves as an internal standard, tracer, and reference compound in chromatographic and mass spectrometric analyses, and is supplied with supporting documentation for laboratory use.
High purity analytical reagent suitable for standards and calibration.
Useful as an internal standard or tracer in GC/MS and chromatographic methods.
Chemical formula C17H36; molecular weight 240.47 g/mol.
Available in laboratory pack sizes including 50 G.
Storage recommendations: pure form at -20°C (long-term) or 4°C (short-term); in solvent at -80°C for extended stability.
Documentation available: data sheet, SDS, COA.
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MD-224 is a PROTAC small molecule degrader that targets MDM2 for proteasomal degradation and is supplied for research use in cellular and biochemical studies of MDM2-p53 pathways and anticancer mechanisms.
Targets MDM2 for proteasomal degradation
Suitable for cellular and biochemical assays
Molecular formula C48H43Cl2FN6O6; molecular weight 889.80 g/mol
CAS number 2136247-12-4
Available in 1 G pack
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