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Organic compounds that consists entirely of hydrogen and carbon elements usually organized in a chain; some may have a cyclic structure. Includes hydrocarbons that have additional functional groups such as aromatic rings.
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ATN-224 is an orally active Cu2+/Zn2+-superoxide dismutase 1 (SOD1) inhibitor that inhibits SOD1 activity in endothelial cells in a dose-dependent manner with an IC50 of 17.5 nM.
Specific and high affinity for copper ions.
Inhibits the proliferation of HUVEC (IC50=1.4±0.3 μM).
Inhibits the activity of purified bovine SOD1 with an IC50 of 0.33±0.03 μM.
SOD1 inhibition is time-dependent, reaching maximal inhibition by depleting copper.
Inhibits FGF-2-induced ERK1/2 phosphorylation.
Orally-available inorganic small molecule that inhibits Cu/Zn-SOD1 in endothelial and tumor cells.
Significantly inhibits angiogenesis in the Matrigel plug model in mice.
Angiogenesis inhibition occurs independently of copper depletion.
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Dimethyl pentadecanedioate (pentadecanedioic acid, 1,15-dimethyl ester) is the dimethyl ester derivative of pentadecanedioic acid supplied for laboratory research. It is used as a reagent and synthetic intermediate in organic synthesis and biochemical studies. The material is provided with quality documentation and is intended for research use only, not for human or clinical use.
High purity (≈99.0%).
CAS number 36575-82-3 for unambiguous identification.
Molecular weight 300.43 g/mol.
Chemical formula C17H32O4.
Supplied with certificate of analysis for batch verification.
Available in gram-scale packaging for laboratory use.
Suitable as a synthetic intermediate and research reagent.
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An esterified version of the free acid which is less water soluble but more amenable for the formulation of stearate-containing diets and dietary supplements
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