Organooxygen compounds
Medchemexpress LLC PRT062607 hydrochloride (P505-15 hydrochloride) | 1370261-97-4 | C19H24ClN9O | 1 ML
PRT062607 Hydrochloride (P505-15 Hydrochloride) is an orally available Syk inhibitor with an IC50 of 1 nM. It inhibits inflammation and induces apoptosis, demonstrating potent antitumor activity in tumor xenograft mouse models. In vitro, it also exhibits significant activity against a variety of kinases, including Fgr, MLK1, Yes, Flt3, PAK5, Lyn, cSRC, Lck, Pyk, and FAK.
- Inhibits phosphorylation of ERK(Y204), AKT(S473), and SYK(Y352) in Ramos cells
- Inhibits BLNK Tyr84 phosphorylation
- Induces apoptosis in human whole blood
- Shows dose-dependent anti-inflammatory activity in rodent models of rheumatoid arthritis
- Inhibits B-cell activation
- Prevents tumor formation in mouse xenograft models
Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 25 MG
EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor with an IC50 of 0.4 nM. This compound reduces levels of H3K79me2 and H3K79me1, leading to a significant down-regulation of HOXA9 and MEIS1 expression. It selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis of leukemia cells, making it suitable for leukemia research.
- Effective and selective DOT1L inhibitor
- Reduces H3K79me2 and H3K79me1 levels
- Down-regulates HOXA9 and MEIS1 expression
- Selectively inhibits MLL rearrangement cell proliferation
- Promotes differentiation and apoptosis of leukemia cells
- Potent DOT1L enzyme activity inhibition (IC50 of 400±100 pM)
- Demonstrates selectivity over other histone methyltransferases (HMTs)
eMolecules 29671-92-9 | Chloroformamidine hydrochloride | Oakwood Chemicals | MFCD00035527 | 114.960 | CH4Cl2N2 | 97.000 | Cl.NC(Cl)=N | 1g | 480138803
Chloroformamidine hydrochloride | Oakwood Chemicals | 29671-92-9 | MFCD00035527 | 114.960 | CH4Cl2N2 | 97.000 | Cl.NC(Cl)=N | 1g | 480138803
Medchemexpress LLC Amelparib hydrochloride | 98.4% | 379.88 | 10 MG
Amelparib hydrochloride is a potent, orally active, and water-soluble inhibitor of PARP-1. It inhibits PARP-1 activity and cellular PAR formation, acting as a potential neuroprotective agent.
- Potent, orally active, and water-soluble inhibitor of PARP-1
- Inhibits PARP-1 activity (IC50 = 18.5 nM)
- Inhibits cellular PAR formation (IC50 = 10.7 nM)
- Potential neuroprotective agent
- Potential for the research of acute ischaemic stroke
Medchemexpress LLC Befiradol hydrochloride | 2436760-81-3 | MFCD31731608 | 99.9% | 430.32 g/mol | C20H23Cl2F2N3O | 10 MG
Befiradol hydrochloride is a selective 5-HT1A receptor agonist provided for research use. It modulates serotonergic and dopaminergic activity in cortical regions and is used in preclinical pharmacology studies to investigate 5-HT1A-mediated mechanisms and models of neurological disorders. The material is supplied with supporting documentation for analytical and safety purposes.
- Selective 5-HT1A receptor agonist for receptor pharmacology studies.
- Demonstrated activity on dorsal raphe and medial prefrontal cortex neurotransmission.
- High chemical purity suitable for analytical and in vivo research.
- Supplied with certificate of analysis and safety data sheet.
- Available in multiple pack sizes for small-scale and bulk use.
- Not for human or clinical use; for research use only.
Medchemexpress LLC Alosetron Hydrochloride | 122852-69-1 | 99.6% | C17H19ClN4O | 10 MM * 1 ML
Alosetron Hydrochloride (GR 68755C) is a potent and highly selective serotonin 5-HT3 receptor antagonist, utilized for irritable bowel syndrome (IBS) research. It blocks 5-HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons (IC50 ~55 nM), attenuates visceral nociceptive effects, and demonstrates anti-inflammatory effects.
- Potent and highly selective serotonin 5-HT3 receptor antagonist.
- Used for research of irritable bowel syndrome.
- Blocks 5HT3-mediated depolarisation of neurons.
- Attenuates visceral nociceptive effects.
- Demonstrates anti-inflammatory effects.
eMolecules 51285-26-8 | Picolinimidamide hydrochloride | ChemScene | MFCD00052271 | 157.600 | C6H8ClN3 | 95.000 | Cl.NC(=N)c1ccccn1 | 25g | 572163656
Picolinimidamide hydrochloride | ChemScene | 51285-26-8 | MFCD00052271 | 157.600 | C6H8ClN3 | 95.000 | Cl.NC(=N)c1ccccn1 | 25g | 572163656
Medchemexpress LLC 1H-Indene-1,3(2H)-dione, 2,2-dihydroxy- | 485-47-2 | 100.0 % | 100 G
Ninhydrin is a chromogenic analytical probe used for the quantification of amino acids and proteins. It reacts with primary and secondary amines, producing a blue or purple reaction product, diketohydrindylidene-diketohydrindamine. It is utilized in the amino acid analysis of proteins; most amino acids, excluding proline, can be hydrolyzed and react with ninhydrin, after which they are colorimetrically quantified following chromatographic separation.
- Chromogenic analytical probe.
- Reacts with primary and secondary amines.
- Solid appearance, white to light yellow color.
- Quantification of amino acids and proteins.
- Useful in amino acid analysis of proteins.
Medchemexpress LLC Eperisone (hydrochloride) | 56839-43-1 | 99.95% | 1 G
Eperisone hydrochloride is an orally active antispastic agent with a vasodilator effect. It is used for the research of muscle stiffness and pain. This compound is a potent and selective P2X7 receptor antagonist, also exhibiting antagonism for human P2X3. It works by relaxing both skeletal muscles and vascular smooth muscles, demonstrating several beneficial effects.
- Reduces myotonia.
- Improves circulation.
- Suppresses the pain reflex.
- Preferentially suppresses lung fibroblast activity.
- Suppresses bleomycin-dependent pulmonary fibrosis.
- Not toxic to alveolar epithelial cells in vitro.
Medchemexpress LLC Buspirone (hydrochloride) | 33386-08-2 | 99.99 % | 1 G
Buspirone hydrochloride is a 5-HT1A receptor agonist that can be used for anxiety and depression research.
- Has cytotoxic effect in lymphocytes.
- Induces ROS formation, MMP collapse, lipid peroxidation, lysosomal damage, and elevation of glutathione disulfide (GSSG) in lymphocytes.
- Reduces anxiety/depression behaviors in C57BL/6N mice.
- Restores IS-shifted β-diversity in the gut microbiota in C57BL/6N mice.
- Reduced TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus.
- Reduced myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon.
- Reduced the IS- or EC-induced gut proteobacteria population.
Medchemexpress LLC Imidapril (hydrochloride) | 89396-94-1 | MFCD00870777 | 99.9% | 100 MG
Imidapril hydrochloride (TA-6366) is an orally active inhibitor of angiotensin-converting enzyme (ACE) and MMP-9. It works by suppressing the conversion of angiotensin I to angiotensin II, which in turn reduces total peripheral resistance and systemic blood pressure. It is used in research for hypertension, type 1 diabetic nephropathy, and chronic heart failure.
- Orally active ACE and MMP-9 inhibitor
- Suppresses conversion of angiotensin I to angiotensin II
- Reduces total peripheral resistance and systemic blood pressure
- Used in research for hypertension
- Used in research for type 1 diabetic nephropathy
- Used in research for chronic heart failure
eMolecules 51285-26-8 | 2-Amidinopyridine Hydrochloride | Accela ChemBio (ASD) | MFCD00052271 | 157.600 | C6H8ClN3 | 95.000 | Cl.NC(=N)c1ccccn1 | 1g | 510407894
2-Amidinopyridine Hydrochloride | Accela ChemBio (ASD) | 51285-26-8 | MFCD00052271 | 157.600 | C6H8ClN3 | 95.000 | Cl.NC(=N)c1ccccn1 | 1g | 510407894
Medchemexpress LLC Lecozotan hydrochloride | 433282-68-9 | 98.7% | 520.02 | 5 MG
Lecozotan hydrochloride (SRA-333) hydrochloride is an orally active and selective antagonist of 5-HT1A with a Ki of 4.5 nM for cloned human 5-HT1A receptor. It enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. This product has the potential for mild-to-moderate Alzheimer's disease (AD) research.
- Orally active and selective 5-HT1A antagonist.
- Enhances the release of glutamate and acetylcholine in the hippocampus.
- Possesses cognitive-enhancing properties.
- Potential for mild-to-moderate Alzheimer's disease research.
Medchemexpress LLC Fadrozole hydrochloride | 102676-31-3 | MFCD02313480 | 99.9% | C14H14ClN3 | 10MG
Fadrozole hydrochloride is a potent, selective, nonsteroidal aromatase inhibitor used in biochemical and pharmacological research to inhibit estrogen biosynthesis. It is supplied as the hydrochloride salt with high reported purity and is commonly used in in vitro assays to evaluate aromatase activity and inhibitor potency. The reported IC50 for aromatase inhibition is 6.4 nM.
- Potent aromatase inhibition (IC50 6.4 nM).
- High purity (>99.9%).
- Supplied as a hydrochloride salt for improved handling and solubility.
- Suitable for in vitro biochemical and pharmacological assays.
- Molecular formula C14H14ClN3.
Medchemexpress LLC Ravidasvir hydrochloride | 1303533-81-4 | MFCD32705191 | 99.9% | 835.82 | C42H52Cl2N8O6 | 50MG
Ravidasvir hydrochloride is the hydrochloride salt of ravidasvir, a pan-genotypic hepatitis C virus (HCV) NS5A inhibitor supplied as a high-purity research compound in solid form. It inhibits HCV replication at low nanomolar concentrations and is provided for laboratory research applications.
- High purity (99.9%).
- White to off-white solid physical form.
- Molecular weight 835.82 g/mol.
- Packaged as 50 MG for research use.
- Storage: sealed at 4°C; in solvent: -80°C (up to 6 months) or -20°C (up to 1 month).
- Provides potent pan-genotypic NS5A inhibition with low nanomolar activity.