Organooxygen compounds
Medchemexpress LLC Tenapanor hydrochloride | 1234365-97-9 | MFCD31631378 | 99.6% | 1217.97 | C50H68Cl6N8O10S2 | 10 MG
Tenapanor hydrochloride is a potent, orally active sodium/hydrogen exchanger 3 (NHE3) inhibitor supplied for research use. It is provided as a white to off-white solid and is available in solid and solution formats for in vitro and in vivo studies.
- Potent NHE3 inhibitor for pharmacology and preclinical research.
- Provided as a white to off-white solid and as solution formulations.
- Reported purity 99.6% with analytical data (COA, HPLC, LCMS) available.
- Soluble in DMSO and water; formulation protocols give clear solutions ≥ 5 mg/mL.
- Recommended storage: 4°C sealed, away from moisture and light; in solvent store at -80°C for long-term.
- For research use only; not for human use or sale to patients.
Medchemexpress LLC VU6036720 hydrochloride | 99.65% | 473.39 | 50 MG
VU6036720 hydrochloride is a potent and specific inhibitor of Kir4.1/5.1 channels. It is suitable for various research applications.
- Inhibits Kir4.1/5.1 channels with an IC50 value of 0.24 μM.
- Can be used for the research of brain and kidney.
Medchemexpress LLC Dopexamine hydrochloride | 86484-91-5 | 429.42 | 5 MG
Dopexamine hydrochloride is a β2 adrenergic receptor agonist and a dopamine analogue with agonist activity at β2 and dopaminergic receptors. It can attenuate systemic inflammatory response, reduce tissue leukocyte infiltration, and protect against organ injury at doses that do not alter global hemodynamics or regional microvascular flow. It also reduces the systemic inflammatory response to endotoxin, including cytokine release, endothelial adhesion molecules, and oxidative stress, without substantially changing systemic hemodynamics.
- β2 adrenergic receptor agonist
- Dopamine analogue with agonist activity at β2 and dopaminergic receptors
- Attenuates systemic inflammatory response
- Reduces tissue leukocyte infiltration
- Protects against organ injury
- Reduces systemic inflammatory response to endotoxin, including cytokine release, endothelial adhesion molecules, and oxidative stress
Medchemexpress LLC Azasetron hydrochloride | 123040-16-4 | MFCD00209913 | 99.8% | C17H21Cl2N3O3 | 5 MG
Azasetron hydrochloride is a benzamide derivative functioning as a potent and selective 5-HT3 receptor antagonist. It is utilized in studies concerning chemotherapy-induced nausea and vomiting (CINV).
- Potent and selective 5-HT3 receptor antagonist
- Used in studies for chemotherapy-induced nausea and vomiting (CINV)
- Purity of 99.76%
- Solid, white to off-white appearance
- Effectively penetrates skin in in vivo studies
- IC50 for 5-HT3 Receptor is 0.33 nM
Medchemexpress LLC Ribociclib hydrochloride | 1211443-80-9 | >99.9% | 471.00 | 10 MG
Ribociclib hydrochloride is an ATP-competitive and orally active CDK4/6 inhibitor designed for research use. It effectively crosses the blood-brain barrier and demonstrates potent inhibitory activity against CDK4 and CDK6.
- ATP-competitive and orally active CDK4/6 inhibitor
- Crosses the blood-brain barrier
- IC50 values of 10 nM for CDK4 and 39 nM for CDK6
- Over 1,000-fold less potent against the cyclin B/CDK1 complex
- Induces cell-cycle arrest in G0/G1 phase
- Significantly delays tumor growth in neuroblastoma xenografts
Medchemexpress LLC Ravidasvir (hydrochloride) | 1303533-81-4 | MFCD32705191 | 99.9% | 835.82 | C42H52Cl2N8O6 | 5MG
Ravidasvir hydrochloride is the hydrochloride salt of ravidasvir, a pan-genotypic hepatitis C virus (HCV) NS5A inhibitor supplied for research use. It is provided as solid vials in multiple sizes and as DMSO solutions for immediate assay use. Intended for in vitro research and assay development; not for human or clinical use.
- High purity suitable for analytical and biological research.
- Multiple solid vial sizes available, including small research quantities.
- Available as a ready-to-use 10 mM solution in DMSO for rapid testing.
- Molecular weight 835.82 and formula C42H52Cl2N8O6 for precise calculations.
- CAS number 1303533-81-4 for unambiguous identification.
Medchemexpress LLC SSR180711 hydrochloride | 446031-79-4 | 99.9% | 361.66 | 25 MG
SSR180711 hydrochloride | 446031-79-4 | 99.9% | 361.66 | 25 MG
Medchemexpress LLC Oxyfedrine hydrochloride | 16777-42-7 | MFCD01695148 | 99.9% | 349.85 g/mol | C19H24ClNO3 | 1 ML
Oxyfedrine hydrochloride is a β-adrenoreceptor agonist supplied as a ready-to-use 10 mM solution in DMSO (1 mL) for research applications. The accurately prepared solution simplifies assay setup and reduces measurement variability. Storage and handling recommendations are provided to maintain product stability.
- Prepared 10 mM solution in DMSO, 1 mL.
- High purity (99.9% by HPLC).
- Suitable for in vitro assays and compound screening.
- Includes storage and stability guidance for solvent and solid forms.
- Molecular formula C19H24ClNO3; molecular weight 349.85 g/mol.
Medchemexpress LLC Nordoxepin hydrochloride | 2887-91-4 | MFCD00135797 | 99.9% | 301.81 g·mol⁻¹ | C18H20ClNO | 1 ML
Nordoxepin hydrochloride is the hydrochloride salt of nordoxepin (desmethyldoxepin), the primary metabolite of the tricyclic antidepressant doxepin. It is intended for research and analytical applications and is supplied as a ready-to-use 10 mM solution in DMSO (1 mL) and in multiple solid mass formats for analytical and synthetic workflows.
- High purity suitable for research applications (99.94%).
- Supplied as a ready-to-use 10 mM solution in DMSO for convenient dosing.
- Available in multiple solid mass sizes for synthetic and analytical work.
- Molecular weight 301.81 g·mol⁻¹ and formula C18H20ClNO for easy reference.
- Storage guidance: solid at 4°C; solution at -80°C (up to 6 months) or -20°C (up to 1 month).
Medchemexpress LLC Pargyline hydrochloride | 306-07-0 | 99.9% | C11H14ClN | 1 ML
Pargyline hydrochloride is an irreversible monoamine oxidase (MAO) inhibitor with Kis of 13 μM for MAO-A and 0.5 μM for MAO-B. It exhibits antihypertensive and anticancer activities. Pargyline (hydrochloride) is also a click chemistry reagent, containing an Alkyne group, which can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that have Azide groups.
- Irreversible monoamine oxidase (MAO) inhibitor
- Inhibits MAO-A with a Ki of 13 μM
- Inhibits MAO-B with a Ki of 0.5 μM
- Demonstrates antihypertensive activities
- Exhibits anticancer activities
- Functions as a click chemistry reagent
- Contains an Alkyne group for CuAAc reactions
Medchemexpress LLC Fadrozole hydrochloride hemihydrate | 176702-70-8 | 99.6% | 268.74 | 25 MG
Fadrozole hydrochloride hemihydrate is an orally active, potent, selective, and nonsteroidal aromatase inhibitor, with an IC50 of 6.4 nM. It inhibits the production of estrogen and progesterone, with IC50 values of 0.03 and 120 μM, respectively. This compound shows prevention of spontaneous tumors and can be used for research on estrogen-dependent diseases and cancer.
- Orally active
- Potent, selective, and nonsteroidal aromatase inhibitor (IC50 of 6.4 nM)
- Inhibits estrogen production (IC50 of 0.03 μM)
- Inhibits progesterone production (IC50 of 120 μM)
- Prevents spontaneous tumors
- Useful for research of estrogen-dependent diseases and cancer
![Medchemexpress LLC Benzoic acid, 4-[4-[[(3R)-1-butyl-3-[(R)-cyclohexylhydroxymethyl]-2,5-dioxo-1,4,9-triazaspiro [5.5]undec-9-yl]methyl]phenoxy]-, hydrochloride (1:1) | 461023-63-2 | 99.9% | 614.17 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000386677-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzoic acid, 4-[4-[[(3R)-1-butyl-3-[(R)-cyclohexylhydroxymethyl]-2,5-dioxo-1,4,9-triazaspiro [5.5]undec-9-yl]methyl]phenoxy]-, hydrochloride (1:1) | 461023-63-2 | 99.9% | 614.17 | 1 ML
Aplaviroc hydrochloride, an SDP derivative, is a potent CCR5 antagonist. It exhibits strong activity against various HIV-1 strains, including wild-type and multidrug-resistant variants, by binding to CCR5 with high affinity and inhibiting gp120/CD4 binding. This compound has been shown to suppress R5 HIV-1 viremia in in vivo models.
- Potent activity against three wild-type R5 HIV-1 strains (HIV-1Ba-L, HIV-1JRFL, and HIV-1MOKW).
- Substantially more potent than previously published CCR5 inhibitors.
- Suppresses infectivity and replication of two HIV-1MDR variants.
- Binds to CCR5 with high affinity.
- Potently blocks rgp120/sCD4 binding to CCR5.
- Exerts potent anti-R5 human immunodeficiency virus type 1 effects in a novel AIDS mouse model.
- Suppresses R5 HIV-1 viremia in hu-PBMC-NOG mice.
Medchemexpress LLC AMXI-5001 hydrochloride | 00-00-0 | 98.1% | C25H21ClFN5O3 | 10MG
AMXI-5001 hydrochloride is a research-grade small molecule described as a dual inhibitor of PARP1/2 and microtubule polymerization. It shows potent cellular activity against PARP and tubulin targets, with reported favorable metabolic stability and oral bioavailability, and is intended for preclinical anticancer research.
- Dual mechanism: inhibits PARP1/2 and tubulin polymerization.
- Potent PARP inhibition with low nanomolar IC50s and tubulin inhibition in the micromolar range.
- Orally bioavailable with favorable pharmacokinetic properties.
- Suitable for in vitro and in vivo anticancer studies.
- High purity for research applications.
Medchemexpress LLC Berubicin hydrochloride | 293736-67-1 | 95.1% | 670.10 | 1 MG
Berubicin hydrochloride is an analog of Doxorubicin that can cross the blood-brain barrier. It inhibits P-gp and MRP1-mediated efflux and suppresses glioblastoma multiforme (GBM). This product exerts toxic effects on leukemia cells by activating nuclear factor κB (NF-κB) and induces apoptosis in neuroblastoma cells. It can be used in the study of tumors related to the nervous system.
- Crosses the blood-brain barrier
- Inhibits P-gp and MRP1-mediated efflux
- Suppresses glioblastoma multiforme (GBM)
- Activates nuclear factor κB (NF-κB)
- Induces apoptosis in neuroblastoma cells
- More potent activity than Doxorubicin in activating NF-κB and inhibiting DNA synthesis
- Prolongs survival time in intracranial orthotopic glioma models in mice
Medchemexpress LLC R-(+)-SCH-23390 hydrochloride | 125941-87-9 | 99.8% | 324.24 | 25 MG
R-(+)-SCH-23390 hydrochloride | 125941-87-9 | 99.8% | 324.24 | 25 MG