Organooxygen compounds
Medchemexpress LLC SB-277011 hydrochloride | 215804-67-4 | 99.59% | 475.02 | 50 MG
SB-277011 hydrochloride is a potent and selective dopamine D3 receptor (D3R) antagonist, demonstrating high oral bioavailability and brain penetrance. It exhibits significant selectivity over other dopamine receptors and possesses an excellent pharmacokinetic profile in rats. This compound has been shown to effectively reverse the effects of quinelorane and reduce cocaine self-administration in preclinical studies.
- Potent and selective D3 receptor antagonist
- High oral bioavailability and brain penetrance
- 80- to 100-fold selectivity over other dopamine receptors
- Excellent pharmacokinetic profile
- Reverses quinelorane effects in nucleus accumbens
- Reduces intravenous cocaine self-administration
- Inhibits basal and cocaine-enhanced locomotion
- Appearance: solid, off-white to light yellow
Medchemexpress LLC Clorgyline hydrochloride | 17780-75-5 | 99.9% | C13H16Cl3NO | 100 MG
Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) used in scientific research. It is structurally related to Pargyline. It has little effect on the amounts of conjugated dopamine (DA) in superfusate of slices from rat striatum. It contains an Alkyne group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. This product is for research use only, not sold to patients.
- Irreversible and selective inhibitor of monoamine oxidase A (MAO-A)
- Used in scientific research
- Structurally related to Pargyline
- Has little effect on conjugated dopamine (DA) in superfusate of slices from rat striatum
- Contains an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC SAR407899 hydrochloride | 923262-96-8 | MFCD20485429 | 99.1% | 280.75 g/mol | C14H17ClN2O2 | 10 MG
SAR407899 hydrochloride is a selective, potent, ATP-competitive inhibitor of Rho-associated kinases (ROCK), supplied as a high-purity solid for preclinical biochemical and cellular research. It is used to probe ROCK-mediated signaling, vascular tone, and smooth muscle responses in vitro and in vivo.
- Selective ATP-competitive ROCK inhibitor with ROCK-2 IC50 ≈135 nM.
- Demonstrates Ki values of 36 nM (human) and 41 nM (rat).
- High purity (99.1%) suitable for research applications.
- Solid, light yellow to khaki appearance; stable when stored sealed at 4°C.
- Applicable to studies of vascular tone, smooth muscle relaxation, and ROCK signaling pathways.
Medchemexpress LLC VU6036720 hydrochloride | 99.7% | 473.39 | 100 MG
VU6036720 hydrochloride is a potent and specific in vitro inhibitor of Kir4.1/5.1 channels. It can inhibit these channels with an IC50 value of 0.24 μM and is suitable for research related to brain and kidney.
- Potent and specific in vitro inhibitor of Kir4.1/5.1 channels
- Inhibits Kir4.1/5.1 channels with an IC50 value of 0.24 μM
- Can be used for the research of brain and kidney
Medchemexpress LLC CZC-54252 hydrochloride | 1784253-05-9 | 98.4% | 5 MG
CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50 values of 1.28 nM for wild-type LRRK2 and 1.85 nM for G2019S LRRK2. This compound can attenuate G2019S LRRK2-induced human neuronal injury with an EC50 of approximately 1 nM, exhibiting neuroprotective activity.
- Potent and selective LRRK2 inhibitor
- Attenuates G2019S LRRK2-induced human neuronal injury
- Exhibits neuroprotective activity
- Molecular weight: 541.45
- Chemical formula: C22H26Cl2N6O4S
- Appearance: Solid
- Color: Light yellow to orange
- Recommended storage: 4°C, sealed, away from moisture
Medchemexpress LLC SKF-34288 hydrochloride (3-Mercaptopicolinic acid hydrochloride) | 320386-54-7 | 98.6% | 100 MG
SKF-34288 hydrochloride (3-Mercaptopicolinic acid) is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor with a Ki of 2-9 μM. It acts as a potent hypoglycemic agent by inhibiting glucose synthesis and also inhibits Asn metabolism, leading to an increase in amino acids and amides.
- Orally active PEPCK inhibitor (Ki: 2-9 μM)
- Potent hypoglycemic agent that inhibits glucose synthesis
- Inhibits Asn metabolism
- Increases amino acids and amides
- Reduces blood glucose in starved rats
- Neutralizes Salbutamol-mediated hyperglycaemia in rabbits
- Reduces pyruvate-induced blood glucose level in rats
- Inhibits C2C12 cell proliferation
- Induces myogenic differentiation of C2C12 cells
Medchemexpress LLC PhiKan 083 hydrochlo | 1050480-30-2 | 99.3% | 274.79 | 10 MG
PhiKan 083 hydrochloride is a carbazole derivative that functions as a p53 Y220C stabilizer. It binds to the surface cavity of the Y220C (a p53 mutant) with a Kd of 167 μM and demonstrates a relative binding affinity (Kd) of 150 μM in Ln229 cells. This compound has been shown to slow down the thermal denaturation rate of p53 Y220C.
- Binds to the surface cavity of p53 Y220C mutant.
- Stabilizes p53 Y220C.
- Exhibits a Kd of 167 μM for p53 Y220C.
- Shows a relative binding affinity of 150 μM in Ln229 cells.
- Slows the thermal denaturation rate.
- Reduces cell viability of engineered Ln229 cell variants.
- Enhances pro-apoptotic activity in Ln229 cells when combined with NSC 123127.
Medchemexpress LLC NNMT-IN-6 hydrochloride | 3031756-18-7 | 98.2% | C25H30ClN7O5 | 10MG
NNMT-IN-6 hydrochloride is the hydrochloride salt of a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) intended for research use. It exhibits in vitro inhibitory activity (IC50 = 1.41 μM; Kd = 5.6 μM) and is supplied as a high-purity solid with documented solubility and storage recommendations for biochemical and cellular assays.
- High purity (98.2%).
- Confirmed NNMT inhibitory activity (IC50 = 1.41 μM; Kd = 5.6 μM).
- Hydrochloride salt form for improved solubility.
- Validated solubility in DMSO and water (250 mg/mL with sonication).
- Suitable for biochemical and cellular assays targeting NNMT.
- Recommended sealed storage away from moisture, with solvent stability guidelines.
Medchemexpress LLC Viloxazine hydrochloride | 35604-67-2 | MFCD00661100 | 98.9% | 273.75 g/mol | C13H20ClNO3 | 50MG
Viloxazine hydrochloride is a research-grade small molecule used as a selective norepinephrine transporter (NET) inhibitor and a modulator of serotonin (5-HT) receptors. Presented as the hydrochloride salt (CAS 35604-67-2) and supplied for preclinical laboratory use, it is commonly employed as a tool compound in studies of norepinephrine and serotonin signaling and in ADHD-related research.
- Research-grade hydrochloride salt with defined purity for laboratory use.
- Selective norepinephrine transporter inhibitor activity (IC50 = 0.26 μM).
- Modulates 5-HT receptors, including 5-HT2B antagonist and 5-HT2C agonist actions.
- Available in small pack sizes suitable for assays, including a 50 mg pack.
- Provided with molecular and analytical data to support traceability and reproducibility.
Medchemexpress LLC Abeprazan hydrochloride | 1902954-87-3 | 99.9% | 446.87 | 50 MG
Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker that inhibits H+, K+- ATPase through reversible potassium-competitive ionic binding without requiring acid activation. It is being developed as a potential alternative to proton pump inhibitors for treating acid-related diseases.
- Potassium-competitive acid blocker.
- Inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding.
- Does not require acid activation for its inhibitory mechanism.
- Developed as a potential alternative for proton pump inhibitors.
- Inhibits acid secretion in a dose-dependent manner in in vivo studies.
- Efficacy is equal to or greater than that of vonoprazan in various in vivo studies.