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BCI-137 is a competitive small-molecule inhibitor of Argonaute 2 (AGO2) that binds residues in the MID domain and inhibits AGO2 activity (reported IC50 342 μM). It is supplied as a white to off-white solid intended for research use.
Competitive AGO2 inhibitor; IC50 342 μM.
High purity solid (listed purity 98.88%).
Molecular formula C11H11N3O6S; molecular weight 313.29 g·mol⁻¹.
Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
Supplied as a 25 mg package for laboratory research.
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BI-2545 is a potent autotaxin (ATX) inhibitor developed as a chemical probe for in vitro and in vivo research. It exhibits single-digit nanomolar potency against purified ATX and lowers plasma lysophosphatidic acid (LPA) levels in animal studies, with demonstrated oral activity in rats. The compound is provided as a solid and has reported chemical identifiers and physical properties suitable for laboratory use.
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Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of the TET enzyme, with IC50 values of 33 μM for TET1 and 73 μM for TET2. It is valuable in the field of epigenetics and serves as a foundation for developing new therapeutics targeting DNA methylation and gene transcription.
Potent and selective cytosine-based inhibitor of TET enzyme.
Useful in epigenetics research.
Serves as a starting point for new therapeutics targeting DNA methylation and gene transcription.
Inhibitory activity is directly related to Cu(II) content; the Bobcat339-copper mixture shows significantly higher TET inhibition than either alone.
Significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells at 10 μM for 24 hours.
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Nifenalol hydrochloride is a β-adrenergic receptor antagonist used in cardiac electrophysiology and pharmacology research. The compound is reported to induce early afterdepolarization (EAD) and is used to study arrhythmia and blood pressure-related effects.
Beta-adrenergic receptor antagonist activity
Induces early afterdepolarization useful for arrhythmia studies
Hydrochloride salt form for improved solubility
Molecular formula C11H17ClN2O3
Molecular weight 260.72
Available in small research pack sizes (e.g., 5 mg)
Intended for in vitro and in vivo research applications
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Pargyline hydrochloride is an irreversible monoamine oxidase (MAO) inhibitor with antihypertensive and anticancer activities. It functions as a click chemistry reagent, containing an Alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Irreversible monoamine oxidase (MAO) inhibitor
Exhibits antihypertensive activities
Demonstrates anticancer activities
Functions as a click chemistry reagent
Contains an alkyne group for CuAAc reactions
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PRT062607 Hydrochloride is an orally available Syk inhibitor that effectively inhibits inflammation and induces apoptosis. It demonstrates potent antitumor activity in tumor xenograft mouse models. This compound inhibits phosphorylation of ERK, AKT, and SYK in Ramos cells, and BLNK Tyr84 phosphorylation in a concentration-dependent manner.
Inhibits B cell antigen receptor-mediated B cell signaling and activation
Inhibits Fc receptor 1-mediated induced basophil degranulation
Produces dose-dependent anti-inflammatory activity in rodent models of rheumatoid arthritis
Prevents BCR-induced splenomegaly in mice
Prevents Ramos tumor formation in mouse xenograft models
Significantly inhibits NHL tumor growth in xenograft models
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AMXI-5001 hydrochloride is a research-grade small molecule described as a dual inhibitor of PARP1/2 and microtubule polymerization. It shows potent cellular activity against PARP and tubulin targets, with reported favorable metabolic stability and oral bioavailability, and is intended for preclinical anticancer research.
Dual mechanism: inhibits PARP1/2 and tubulin polymerization.
Potent PARP inhibition with low nanomolar IC50s and tubulin inhibition in the micromolar range.
Orally bioavailable with favorable pharmacokinetic properties.
Suitable for in vitro and in vivo anticancer studies.
High purity for research applications.
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OTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. It significantly inhibits tumor growth in mouse xenograft models without detectable toxicity and regulates the production of γ-H2AX in cancer cells.
Potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM.
Shows significant inhibition of tumor growth in mouse xenograft models.
Does not exhibit any detectable toxicity in mouse xenograft models.
Regulates the production of γ-H2AX in cancer cells.
Inhibits A549 cell growth with an IC50 of 0.67 μM.
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A selective sphingosine kinase 2 (SphK2) inhibitor supplied as the hydrochloride salt for research use. Solid, high-purity material characterized by molecular formula C22H31ClF3N5O2 and molecular weight 489.96 Da.
Selective sphingosine kinase 2 inhibitor for biochemical and cellular studies.
Hydrochloride salt form, supplied as a solid powder.
High purity (reported 99.1%), suitable for research applications.
Soluble in water at approximately 40 mg/mL with ultrasonic warming if required.
Recommended storage: long-term in solvent at -80°C, short-term at -20°C, sealed and away from moisture.
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AkaLumine hydrochloride is a D-luciferin analogue with a Km of 2.06 μM for recombinant firefly luciferase (Fluc) protein. It emits near-infrared (NIR) light (λmax=677 nm) in reactions with native Fluc, offering high tissue-penetration and increased detection sensitivity for deep-tissue targets. It is intended for research use only and not for sale to patients.
D-luciferin analogue
Km of 2.06 μM for recombinant firefly luciferase protein
Emits near-infrared (NIR) light (λmax=677 nm) in reactions with native Fluc
High tissue-penetration
Increases detection sensitivity from deep-tissue targets
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