AMXI-5001 hydrochloride is a potent, orally active, and dual PARP1/2 and microtubule polymerization inhibitor. It shows selective antitumor cytotoxicity across a wide range of human cancer cells with significantly lower IC50s compared to existing clinical PARP1/2 inhibitors, and can induce complete regression of established tumors, including very large ones.
- Potent and orally active
- Dual PARP1/2 and microtubule polymerization inhibitor
- Selective antitumor cytotoxicity across a wide range of human cancer cells
- Significantly lower IC50s compared to existing clinical PARP1/2 inhibitors
- Induces complete regression of established tumors