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1-Isothiocyanato-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Used in the synthesis of PROTACs.
PROTACs contain two different ligands connected by a linker.
Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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