Camptothecin-d5 is the deuterium labeled Camptothecin. Camptothecin (CPT), an alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. It shows strong antineoplastic activity against colorectal, breast, lung, and ovarian cancers, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering microRNA (miRNA) expression patterns in human cancer cells.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.