Tegoprazan is a potassium-competitive acid blocker, a reversible, orally active, and highly selective inhibitor of gastric H+/K+-ATPase. It inhibits gastric acid secretion and motility against porcine, canine, and human H+/K+-ATPase with IC50 values ranging from 0.29-0.52 μM in vitro. It also significantly improves colitis and enhances the intestinal epithelial barrier function in mice, making it promising for research of inflammatory bowel, gastric acid-related, and motility-impaired diseases.
- Reversible, orally active, and highly selective inhibitor of gastric H+/K+-ATPase.
- Inhibits gastric acid secretion and motility.
- Improves colitis and enhances intestinal epithelial barrier function.
- Promising for research of inflammatory bowel, gastric acid-related, and motility-impaired diseases.