Pamoic Acid
Cayman Chemical PamoIc AcId 250g
A potent agonist of GPR35 orphan receptors (EC50 = 79 nM in a β-arrestin recruitment assay); induces GPR35 translocation from the plasma membrane to the cytoplasm (EC50 =22 nM); increases ERK1/2 phosphorylation in a concentration-dependent manner in U20S cells expressing human GPR35a; has antinociceptive effects in a mouse abdominal constriction model of visceral pain perception (ED50 = 40.5 mg/kg)
Cayman Chemical PamoIc AcId 100g
A potent agonist of GPR35 orphan receptors (EC50 = 79 nM in a β-arrestin recruitment assay); induces GPR35 translocation from the plasma membrane to the cytoplasm (EC50 =22 nM); increases ERK1/2 phosphorylation in a concentration-dependent manner in U20S cells expressing human GPR35a; has antinociceptive effects in a mouse abdominal constriction model of visceral pain perception (ED50 = 40.5 mg/kg)
Medchemexpress LLC Pamoic acid (Embonic acid) | 130-85-8 | 99.7% | 388.38 | 100 G
Pamoic acid (Embonic acid) is a potent GPR35 agonist that demonstrates neuroprotective and anti-inflammatory properties. Its GPR35 activation may increase the phosphorylation of ERK1/2, which helps to suppress NF-κB-dependent inflammatory genes.
- Potent GPR35 agonist with an EC50 of 79 nM.
- Shows agonist activity at human GPR35 in CHO cell lines.
- Demonstrates neuroprotective activity in a mouse stroke model.
- Reduces infarct size in a GPR35-dependent manner.
- Increases noninflammatory Ly-6CLo monocytes/macrophages in the ischemic brain.
- Reduces neutrophil counts.