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Medchemexpress LLC Pamoic acid (Embonic acid) | 130-85-8 | 99.7% | 388.38 | 100 G
SDP

Supplier:  Medchemexpress LLC HYW008613100G

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Pamoic acid (Embonic acid) is a potent GPR35 agonist that demonstrates neuroprotective and anti-inflammatory properties. Its GPR35 activation may increase the phosphorylation of ERK1/2, which helps to suppress NF-κB-dependent inflammatory genes.

  • Potent GPR35 agonist with an EC50 of 79 nM.
  • Shows agonist activity at human GPR35 in CHO cell lines.
  • Demonstrates neuroprotective activity in a mouse stroke model.
  • Reduces infarct size in a GPR35-dependent manner.
  • Increases noninflammatory Ly-6CLo monocytes/macrophages in the ischemic brain.
  • Reduces neutrophil counts.

Catalog No. 50-004-52556


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