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Trifluoroacetic Acid

Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.

Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:

  • Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
  • Dissolves protein when mixed with liquid SO2
  • Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
  • Can remove the t-butoxycarbonyl protecting group in organic synthesis
  • At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
  • For acid-stable materials, can be a solvent for NMR spectroscopy
  • Acts as a calibrant in mass spectrometry
  • Used to produce trifluoroacetate salts
  • An ingredient in adhesives, sealants, paints, and coatings

 

When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.

Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.

TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.

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Trifluoroacetic acid, 99+%, for HPLC
GREENER_CHOICE

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: 2,2,2-trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name 2,2,2-trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
2

Trifluoroacetic acid, 99.5%, for biochemistry

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
3

Trifluoroacetic acid, 99+%, extra pure

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
4
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Trifluoroacetic Acid (For Peptide and Protein Analysis/Certified), Fisher Chemical

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
5
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Trifluoroacetic Acid (Reagent), Fisher Chemical

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
6
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Trifluoroacetic Acid, Optima™ LC/MS Grade, Fisher Chemical™
GSA_VA

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
7

Trifluoroacetic acid, 99+%, for spectroscopy

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: 2,2,2-trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name 2,2,2-trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
8

Trifluoroacetic acid, 99%

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
9

Thermo Scientific Chemicals Trifluoroacetic acid, biochemical grade, 99.5+%

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
10

Trifluoroacetic acid, 99.5+%

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
11

eMolecules​ 2411759-92-5 | Medchem Express | EZM0414 (TFA) | 5mg | 592903606 | HY-136328 | 514.522 | C24H30F4N4O4

8-Bromo-quinolin-4-ol | Chemcia | 57798-00-2 | MFCD00272389 | 224.057 | C9H6BrNO | 96.000 | Oc1ccnc2c(Br)cccc12 | 25g | 210210476

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Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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12

Covachem Trifluoroacetic Acid | 76-05-1 | MFCD00004169 | 10 x 1 mL

This item has a minimum order quantity of 2 per supplier requirements.

Trifluoroacetic Acid | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 | 10 x 1 mL

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13

eMolecules​ 1810069-99-8 | bis(2,2,2-trifluoroacetic acid);2-(2,2,2-trifluoroethyl)-2,6-diazaspiro[3.3]heptane | MFCD29037458 | 1g

Medchem Express | Azosemide | 10mg | 495799592 | HY-107321 | 27589-33-9 | MFCD00867321 | 370.830 | C12H11ClN6O2S2

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14

Medchemexpress LLC PSMA I&S TFA | 98.15% | 1413.43 | 5 MG
SDP

PSMA I&S (TFA) is a precursor of the 99mTc-labeled PSMA-targeting ligand, intended for research use only.

  • Precursor of 99mTc-labeled PSMA-targeting ligand
  • For research use only

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15

Medchemexpress LLC NCGC00138783 TFA | 99.4% | C28H27F4N7O3S | 25 MG
SDP

NCGC00138783 TFA is a selective inhibitor targeting the CD47/SIRPα axis, directly blocking the interaction between the CD47 and SIRPα axis with an IC50 of 50 μM.

  • Appearance: Solid
  • Color: White to light yellow
  • Molecular weight: 617.62

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