Naphthalenes

AdipoGen Naphthol AS-TR phosphate 2Na

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Chemical. CAS 4264-93-1. Formula C18H13CINNa2O5P. MW BD9837. Naphthol AS-TR Phosphate is a fluorogenic substrate for acid and alkaline phosphatases. Naphthol AS-TR Phosphate is converted to naphthol AS-TR displaying excitation/emission spectra of 388/512nm. The fluorescence is a quantitative marker of acid and alkaline phosphatase activity. Acid and alkaline phosphatases are often used as clinical markers of disease, since the concentration of human acid and alkaline phosphatases undergo pronounced changes in particular diseases, resulting in unusually high or low concentrations. It is a histochemical substrate commonly used in conjunction with diazonium salts to form a specific azo dye for immunohistology, immunoblotting and dot blot applications. Naphthol AS-TR Phosphate is a cyclic-AMP response element-binding protein CREB-CREB binding protein CBP transcription factor complex inhibitor and a potential therapeutic agent for lung cancer.

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Medchemexpress LLC N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-1-propanesulf... | 1392429-79-6 | 99.2% | 569.67 g·mol⁻¹ | C28H33F2N7O2S | 100 MG

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BI-882370 is a potent, selective pan-RAF kinase inhibitor used in preclinical research to probe RAF/MEK/ERK signaling and to evaluate antitumor activity in BRAF-mutant and wild-type models. It binds the ATP site in the DFG-out (inactive) conformation and exhibits sub-nanomolar to low-nanomolar inhibition of BRAF V600E, wild-type BRAF, and CRAF, making it useful as a research tool for pathway modulation and efficacy studies.

• Potent RAF kinase inhibition with sub-nanomolar to low-nanomolar activity.
• Binds the ATP site in the DFG-out (inactive) conformation.
• Suitable for in vitro and in vivo preclinical studies.
• Supplied in solid and DMSO solution formats for assay flexibility.
• High reported purity appropriate for research applications.

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Medchemexpress LLC Thiobis-β-galactose-propyne | 1989627-40-8 | 98.0% | C27H40O12S2 | 10MG

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Thiobis-β-galactose-propyne is a thiobis-linked galactose derivative used as a multivalent galectin inhibitor in preclinical research. It is supplied as a solid and intended for biochemical and cell-based studies investigating galectin-mediated interactions.

• Multivalent galectin inhibitor suitable for biochemical assays.
• Contains a propyne functional group for click-chemistry conjugation.
• Reported high purity appropriate for in vitro applications.
• Supplied as a solid and stable under recommended frozen storage.
• Available in small mass vials convenient for screening and conjugation work.

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Medchemexpress LLC BI-3812 | 2166387-64-8 | 99.3% | 558.03 | 100 MG

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BI-3812 is a chemical probe and a highly efficient BCL6 inhibitor. It suppresses the BTB domain of BCL6 with an IC50 value of ≤ 3 nM, demonstrating antitumor activity. This product is intended for research use only and not for patient use.

• Highly efficient BCL6 inhibitor
• Suppresses the BTB domain of BCL6 with an IC50 value of ≤ 3 nM
• Exhibits antitumor activity
• Cellular BCL6 IC50 of 40 nM
• Available as a chemical probe

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Medchemexpress LLC Blu-945 | 2660250-10-0 | 99.6% | C28H37FN6O3S | 1 ML

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BLU-945 is a potent, highly selective, reversible, and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKIs). It effectively inhibits EGFR with L858R and/or exon 19 deletion mutation, T790M mutation, and C797S mutation, making it suitable for lung cancer research, including non-small cell lung cancer (NSCLC).

• Potent, highly selective, reversible, and orally active
• Inhibits EGFR with L858R, exon 19 deletion, T790M, and C797S mutations
• Used for research of lung cancer, including non-small cell lung cancer (NSCLC)
• Demonstrates anti-tumor activity in triple-mutant Osimertinib-resistant models

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Medchemexpress LLC CRA-026440 hydrochloride | 847459-98-7 | 98.1% | 456.92 | 1 ML

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CRA-026440 hydrochloride is a potent, broad-spectrum Histone Deacetylase (HDAC) inhibitor. It exhibits antitumor and antiangiogenic activities. This compound also functions as a click chemistry reagent, containing an alkyne group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.

• Potent, broad-spectrum HDAC inhibitor
• Exhibits antitumor and antiangiogenic activities
• Functions as a click chemistry reagent
• Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
• Shows antiproliferative effect on HUVEC endothelial cells
• Inhibits tumor cell growth and induces apoptosis
• Inhibits ex vivo angiogenesis
• Reduces tumor growth in xenograft models

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eMolecules​ 27524-58-9 | [4-(Methoxymethoxy)phenyl]magnesium bromide, 0.50 M in THF | Synthonix241.367 | C8H9BrMgO2 | 0.000 | [Br-].COCOc1ccc([Mg+])cc1 | 100ml | 812262713

[4-(Methoxymethoxy)phenyl]magnesium bromide, 0.50 M in THF | Synthonix | 27524-58-9241.367 | C8H9BrMgO2 | 0.000 | [Br-].COCOc1ccc([Mg+])cc1 | 100ml | 812262713

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eMolecules​ 131554-33-1 | 2-Benzothiazolylmagnesium bromide, 0.50 M in THF | Synthonix238.390 | C7H4BrMgNS | 0.000 | [Br-].[Mg+]c1nc2ccccc2s1 | 100ml | 702445852

2-Benzothiazolylmagnesium bromide, 0.50 M in THF | Synthonix | 131554-33-1238.390 | C7H4BrMgNS | 0.000 | [Br-].[Mg+]c1nc2ccccc2s1 | 100ml | 702445852

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Medchemexpress LLC BI-3231 | 2894848-07-6 | 99.8% | 380.37 | 50 MG

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BI-3231 is a potent and selective chemical probe that inhibits hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), with IC50 values of 1 nM for hHSD17B13 and 13 nM for mHSD17B13. It is being researched for its potential in treating nonalcoholic steatohepatitis (NASH) and other liver diseases.

• Potent and selective hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) inhibitor
• Demonstrates high metabolic stability in liver microsomes
• Moderate metabolic stability in hepatocytes
• Significant hepatic exposure maintained over 48 hours
• Potential for research into nonalcoholic steatohepatitis (NASH) and other liver diseases
• Powder storage: -20°C for 3 years
• In solvent storage: -80°C for 6 months, -20°C for 1 month
• Solubility in DMSO: 125 mg/mL (328.63 mM)

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