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Filtered Search Results
Medchemexpress LLC BI-9627 | 1204329-34-9 | 99.7% | 356.34 Da | C16H19F3N4O2 | 10 MG
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BI-9627 is a potent small-molecule inhibitor of the sodium-hydrogen exchanger isoform 1 (NHE1), used as a research chemical probe to study NHE1-mediated physiology and pharmacology. The compound is supplied as a solid, has a reported molecular formula of C16H19F3N4O2 and a molecular weight of about 356.34 Da, with high reported purity suitable for biochemical and cellular assays.
- Potent NHE1 inhibitor with low-nanomolar activity in cell-based assays
- High chemical purity suitable for biochemical and cellular studies
- Supplied as a solid for ease of handling and storage
- Molecularly characterized with CAS and formula for unambiguous identification
- Useful as a chemical probe for studying sodium-hydrogen exchange pathways
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AA BLOCKS LLC 2-NAPHTHALENECARBOXYLIC AC10G
NC3659609 2-NAPHTHALENECARBOXYLIC AC10G
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Medchemexpress LLC Rolapitant (hydrochloride hydrate) | 914462-92-3 | 98.4% | 554.95 | 25 MG
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Rolapitant (hydrochloride hydrate) | 914462-92-3 | 98.4% | 554.95 | 25 MG
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Medchemexpress LLC 2-Oxa-5-azabicyclo[2.2.1]heptane, 5-[2-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-6-[6-(4-methoxy-3-pyridinyl)-4-methyl-1H-pyrazolo[4,3-c]pyridin-1-yl]-1-methyl-1H-imidazo[4,5-c]pyridin-4-yl]-, (1R,4R)- | 2769715-68-4 | 99.3% | 592.69 | 5 MG
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2-Oxa-5-azabicyclo[2.2.1]heptane, 5-[2-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-6-[6-(4-methoxy-3-pyridinyl)-4-methyl-1H-pyrazolo[4,3-c]pyridin-1-yl]-1-methyl-1H-imidazo[4,5-c]pyridin-4-yl]-, (1R,4R)- | 2769715-68-4 | 99.3% | 592.69 | 5 MG
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Medchemexpress LLC Irinotecan hydrochloride trihydrate | 136572-09-3 | 99.9% | 677.18 | 1 ML
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Irinotecan hydrochloride, also known as (+)-Irinotecan hydrochloride or CPT-11 hydrochloride, is a topoisomerase I inhibitor primarily used in the treatment of colon and rectal cancer. This product is intended for research use only.
- Acts as an inhibitor of topoisomerase I, an enzyme crucial for DNA replication, transcription, and repair.
- Effectively inhibits the growth of various cancer cell lines.
- Suppresses the proliferation of human umbilical vein endothelial cells (HUVEC).
- Significantly inhibits tumor growth in animal models.
- Involved in numerous clinical trials for a wide range of cancers.
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Medchemexpress LLC BI-9787 | 3043939-18-7 | 99.5% | 489.58 | 100 MG
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BI-9787 is a zwitterionic inhibitor for ketohexokinase, with an IC50 of 12 nM for hKHK-A and 12.8 nM for hKHK-C. It shows good metabolic stability in rat hepatocytes and good pharmacokinetic characteristics in rats. The compound was designed by Boehringer Ingelheim and is available through the opnMe.com open innovation portal, along with its negative control. It is intended for research use only and not for sale to patients.
- Purity: 99.46%
- CAS number: 3043939-18-7
- Molecular weight: 489.58
- Formula: C24H29F2N5O2S
- Appearance: Solid
- Color: White to off-white
- IC50 and target: 12 nM (hKHK-A); 12.8 nM (hKHK-C)
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Medchemexpress LLC 2-Butene-1,4-diamine, N1, N4-bis[3-(ethylamino)propyl]-, hydrochloride (1:4), (2Z)- | 206991-64-2 | 95.0% | 402.27 | 25 MG
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PG-11047 (CGC-11047) is a polyamine analogue used for the research of breast cancer. It offers the following features and benefits:
- Inhibits the growth of breast cell lines, with basal-like cell lines being inhibited at lower concentrations than luminal cell lines.
- Causes a significant decrease in S phase fraction at doses that produce little apoptosis.
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Medchemexpress LLC BI-9787 | 3043939-18-7 | 99.5% | 489.58 | 5 MG
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BI-9787 is a zwitterionic inhibitor for ketohexokinase (KHK), demonstrating IC50 values of 12 nM for hKHK-A and 12.8 nM for hKHK-C. It shows good metabolic stability in rat hepatocytes and favorable pharmacokinetic characteristics in rats. This product was designed by Boehringer Ingelheim and is available free of charge through their open innovation portal opnMe.com, alongside its negative control. It is intended for research use only and not for sale to patients.
- Zwitterionic inhibitor for ketohexokinase (KHK)
- IC50 of 12 nM for hKHK-A and 12.8 nM for hKHK-C
- Exhibits good metabolic stability in rat hepatocyte
- Shows good pharmacokinetic characteristics in rats
- Intended for research use only
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Apexbio Technology LLC AZD 5153(Synonyms: AZD5153, AZD-5153, AZD 5153 dihydrochloride, BRD4 inhibitor AZD5153, AZD5153 BRD4 inhibitor), 5mg, CAS: 1869912-39-9.
AZD5153 (CAS 1869912-39-9) is a potent selective orally bioavailable inhibitor of the bromodomain and extraterminal (BET) family protein BRD4 Through simultaneous binding of both bromodomains in BRD4 AZD5153 effectively disrupts BRD4-mediated transcriptional regulation In cellular assays AZD5153 demonstrates high activity notably displacing BRD4 with an IC50 of approximately 1 7 nM in U2OS cells It significantly inhibits growth of AML multiple myeloma and diffuse large B-cell lymphoma cell lines reducing mTOR pathway signaling In vivo AZD5153 shows dose-dependent antitumor efficacy in xenograft models of hematologic malignancies indicating its value as a tool compound in cancer research
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![Medchemexpress LLC 1,8-naphthyridine-1(2H)-carboxamide, 3,4-dihydro-6-[5-(methoxymethyl)-3-pyridinyl]- | 1633009-87-6 | 99.2% | 298.34 g·mol-1 | C16H18N4O2 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000212426.png-250.jpg)
Medchemexpress LLC 1,8-naphthyridine-1(2H)-carboxamide, 3,4-dihydro-6-[5-(methoxymethyl)-3-pyridinyl]- | 1633009-87-6 | 99.2% | 298.34 g·mol-1 | C16H18N4O2 | 1 ML
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BI 689648 is a small-molecule, highly selective aldosterone synthase (CYP11B2) inhibitor used in preclinical research. It potently inhibits CYP11B2 while showing substantially less activity against CYP11B1, and is supplied with molecular characterization, purity data, and solubility/formulation guidance for in vitro and in vivo studies.
- Potent aldosterone synthase inhibition (IC50 2.1 nM).
- Reduced activity against CYP11B1 (IC50 310 nM) for improved selectivity.
- Characterized molecular data (C16H18N4O2; MW 298.34 g·mol-1).
- High purity suitable for research use (99.2% by LCMS).
- Documented solubility and formulation guidance for DMSO and in vivo vehicles.
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Medchemexpress LLC 4-(4-((dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one | 1883429-22-8 | 98.7% | 353.41 | C20H23N3O3 | 10 MG
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BI-9564 is a potent, selective, and cell-permeable inhibitor of BRD9 and BRD7 bromodomains used as a chemical probe in epigenetics research. It exhibits low-nanomolar affinity for BRD9, displays selectivity versus BET family bromodomains, and is supplied as a white to off-white solid for laboratory use.
- Potent inhibition of BRD9 with low-nanomolar affinity.
- Selectivity for BRD9/BRD7 over BET family bromodomains.
- Cell-permeable for use in cellular assays.
- High purity suitable for research applications.
- Supplied as a solid with defined storage recommendations.
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Medchemexpress LLC Isoguvacine (hydrochloride) | 68547-97-7 | 99.8% | 163.60 | C6H10ClNO2 | 1 ML
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Isoguvacine hydrochloride is a GABAA receptor agonist used in neuroscience and pharmacology research to activate GABA receptors. It is supplied as research-grade material, available as a ready-to-use 10 mM stock solution in DMSO or as solid material for custom stock preparation.
- Ready-to-use 10 mM stock solution in DMSO for rapid experimental setup.
- Also available as solid for preparation of custom concentrations.
- High reported purity (~99.8%) suitable for research applications.
- Manufacturer-provided solubility and stock preparation guidance for water and DMSO.
- Storage recommendations listed for both solvent and solid states to maintain stability.
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Aobchem 1-(4-(Methoxymethyl)naphthalen-1-yl)ethanone | 95% | CAS 79996-79-5 | C14H14O2 | 1g
1-(4-(Methoxymethyl)naphthalen-1-yl)ethanone | 95% | CAS 79996-79-5 | C14H14O2 | 1g
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Medchemexpress LLC 3-Amino-2-naphthoic acid | 5959-52-4 | MFCD00004115 | 187.20 | 5 G
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3-Amino-2-naphthoic acid is a naphthalene derivative that can be utilized in the synthesis of other compounds. It is commonly employed as a base material for the creation of various dyes and pigments. Additionally, 3-Amino-2-naphthoic acid has been developed as a "turn-on" fluorescence probe for the specific detection of the cyanate anion (CNO-).
- Utilized in the synthesis of other compounds
- Commonly employed as a base material for the creation of various dyes and pigments
- Developed as a "turn-on" fluorescence probe for the specific detection of the cyanate anion (CNO-)
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Medchemexpress LLC BI-9321 TRIHYDROCHL 10MM/1ML
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BI-9321 TRIHYDROCHL 10MM/1ML
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