Phenanthrenes and derivatives
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Medchemexpress LLC Lurasidone Hydrochloride | 367514-88-3 | 99.9% | C28H37ClN4O2S | 200 MG
Lurasidone Hydrochloride is a 5-HT Receptor Modulator that functions as an antagonist of both dopamine D2 and 5-HT7 receptors. It also acts as a partial agonist of the 5-HT1A receptor. This product is intended for research use only.
- Antagonist of dopamine D2 receptors with an IC50 of 1.68 nM
- Antagonist of 5-HT7 receptors with an IC50 of 0.495 nM
- Partial agonist of 5-HT1A receptors with an IC50 of 6.75 nM
- Demonstrates higher affinity for dopamine D2 and 5-HT2A receptors
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Medchemexpress LLC Vardenafil hydrochloride trihydrate | 330808-88-3 | 99.7% | 200 MG
Vardenafil hydrochloride trihydrate is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM. It shows inhibitory effects towards PDE1 and PDE6 with IC50s of 180 nM and 11 nM, respectively, while IC50s are >1000 nM for PDE3 and PDE4. It competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis, which increases cGMP levels. It can be used for research related to erectile dysfunction, hepatitis, and diabetes.
- It is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5).
- It has an IC50 of 0.7 nM for PDE5.
- It inhibits PDE1 and PDE6 with IC50s of 180 nM and 11 nM.
- It competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis.
- It increases cGMP levels.
- It can be used for the research of erectile dysfunction.
- It can be used for the research of hepatitis.
- It can be used for the research of diabetes.