Unsubstituted Phenols
Medchemexpress LLC RKI-1447 dihydrochloride | 1782109-09-4 | 99.9% | 399.29 | 100 MG
RKI-1447 dihydrochloride is a potent and selective ROCK inhibitor with IC50s of 14.5 and 6.2 nM for ROCK1 and ROCK2, respectively. It suppresses colorectal carcinoma cell growth and promotes apoptosis.
- Potent and selective ROCK inhibitor
- Suppresses colorectal carcinoma cell growth
- Promotes apoptosis
- Suppresses phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells
- Exhibits effective anticancer activity in colorectal carcinoma (CRC)
- Inhibits mammary tumor growth in vivo
- Does not exert physiological toxicity on mice in vivo
Medchemexpress LLC Rki-1447 dihydrochloride | 1782109-09-4 | 99.9% | 399.29 | 10 MG
RKI-1447 dihydrochloride is a potent and selective ROCK inhibitor, effectively suppressing colorectal carcinoma cell growth and promoting apoptosis. It functions by inhibiting ROCK1 (IC50 14.5 nM) and ROCK2 (IC50 6.2 nM), without affecting AKT, MEK, and S6 kinase phosphorylation. This compound has demonstrated significant anticancer activity in both in vitro and in vivo studies, including the inhibition of mammary tumor growth and antitumor effects in colorectal carcinoma.
- Potent and selective ROCK inhibitor
- Suppresses colorectal carcinoma cell growth
- Promotes apoptosis in a dose-dependent manner
- Inhibits phosphorylation of ROCK substrates MLC-2 and MYPT-1
- Exhibits anticancer activity in colorectal carcinoma (CRC)
- Inhibits mammary tumor growth in transgenic mice
- Shows antitumor activity in CRC without physiological toxicity
Medchemexpress LLC PFI-90 | 53995-62-3 | MFCD27925103 | 99.86% | 214.22 | 50 MG
PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. It induces apoptosis and myogenic differentiation, leading to increased cell death. This compound has potential for antitumor activity.
- Selective inhibitor of histone demethylase (KDM3B)
- Inhibits PAX3-FOXO1 action
- Induces apoptosis and myogenic differentiation
- Potential for antitumor activity
Medchemexpress LLC 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide | 53995-62-3 | 99.9% | 214.22 | 100 MG
PFI-90 is a selective inhibitor of histone demethylase (KDM3B) which inhibits PAX3-FOXO1 action. It induces apoptosis and myogenic differentiation, leading to increased cell death, and has potential for antitumor activity. This product is for research use only.
- Selective inhibitor of histone demethylase (KDM3B)
- Induces apoptosis and myogenic differentiation
- Exhibits dose-response in various cell lines (RH4, RH30, OSA-CL, TC-32)
- Increases apoptosis in RH4 and SCMC cells at 3 μM concentration
- Potential for antitumor activity
Medchemexpress LLC Miquelianin (Quercetin 3-O-glucuronide) | 22688-79-5 | 99.9% | 478.36 | 100 MG
Miquelianin (Quercetin 3-O-glucuronide) is a natural flavonoid and a metabolite of quercetin. It acts as a CBR1 inhibitor and is capable of crossing the blood-brain barrier.
- Metabolite of quercetin and natural flavonoid
- Functions as a CBR1 inhibitor
- Permeable to the blood-brain barrier
- Exhibits antioxidant effects in human plasma
- Reduces β-amyloid (Aβ) peptides generation
- Interferes with initial protein-protein interaction of Aβ1-40 and Aβ1-42
- Suppresses ROS generation and signaling pathways
- Inhibits invasion of breast cancer cells
- May act as a dietary chemopreventive factor
Medchemexpress LLC Scutellarin methyl ester | 119262-68-9 | 10 MG
Scutellarin methyl ester is a constituent of Breviscapine, a crude extract of several flavonoids from *Erigeron breviscapus*. This compound has a molecular weight of 476.39 and a chemical formula of C22H20O12. It appears as a solid with a light yellow to yellow color and is classified under flavonoids, flavones, phenols, and polyphenols, with its initial source being plants from other families.
- Chemical formula: C22H20O12
- Molecular weight: 476.39
- Purity: 98.17%
- Appearance: Solid, light yellow to yellow
- Classification: Flavonoid, flavone, phenol, polyphenol
- Initial source: Plants from other families
- Solubility in DMSO: 25 mg/mL (52.48 mM)
- Storage conditions: 4°C protected from light; in solvent, -80°C for 6 months or -20°C for 1 month, protected from light.
Medchemexpress LLC Kuwanon G | 75629-19-5 | 5 MG
Kuwanon G is a flavonoid compound and a bombesin receptor antagonist with various biological activities. It demonstrates strong antibacterial, anti-tumor, anti-inflammatory, antioxidant, anti-atherosclerotic, and neuroprotective effects, making it suitable for research on various diseases such as gastric cancer and atherosclerosis.
- Strong antibacterial activity against oral pathogens.
- Induces apoptosis and inhibits proliferation, migration, and invasion of tumor cells.
- Inhibits mRNA levels of inflammatory factors.
- Protects cells from advanced glycation end product-induced damage.
- Attenuates atherosclerosis by regulating LXRα-ABCA1/ABCG1 and inhibiting NFκB activity.
- Demonstrates neuroprotective effects.
- Acts as a non-peptide bombesin receptor antagonist.
Medchemexpress LLC Chemerin-9 (149-157) (TFA) | 98.2% | 1177.18 | 10 MG
Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1) with anti-inflammatory activity. It stimulates phosphorylation of Akt and ERK, and promotes ROS production. This product also ameliorates Aβ1-42-induced memory impairment and regulates immune responses, adipocyte differentiation, and glucose metabolism.
- Potent agonist of chemokine-like receptor 1 (CMKLR1)
- Exhibits anti-inflammatory activity
- Stimulates phosphorylation of Akt and ERK
- Promotes ROS production
- Ameliorates Aβ1-42-induced memory impairment
- Regulates immune responses, adipocyte differentiation, and glucose metabolism
- Stimulates migration in cardiac fibroblasts
- Alleviates glucose intolerance and IR in PDM mice
- Provides anti-inflammatory and anti-angiogenic effects in ApoE-/- mice
Medchemexpress LLC NUCC-390 dihydrochloride | 2749281-71-6 | 98.2% | 468.46 | 50 MG
NUCC-390 dihydrochloride is a novel and selective small-molecule CXCR4 receptor agonist. It induces internalization of CXCR4 receptors and promotes nerve recovery of function after neurodegeneration in vivo. This product is intended for research use only.
- Selective small-molecule CXCR4 receptor agonist
- Induces internalization of CXCR4 receptors
- Promotes nerve recovery of function after neurodegeneration in vivo
- Supports axonal growth in cultured cerebellar granule neurons
- Aids functional and anatomical recovery of the neuromuscular junction
Medchemexpress LLC Chrysin (5,7-Dihydroxyflavone) | 480-40-0 | 99.75% | C15H10O4 | 500 MG
Chrysin (5,7-Dihydroxyflavone) | 480-40-0 | 99.75% | C15H10O4 | 500 MG
Medchemexpress LLC 4-Hydroxytamoxifen | 68392-35-8 | 99.6% | 387.51 | 50 MG
(E/Z)-4-Hydroxytamoxifen is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. It is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, and an active metabolite of Tamoxifen. It acts as an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). It is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity.
- Racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers
- Selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity
- Active metabolite of Tamoxifen
- Agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM)
- Promising for research of cyclical mastalgia, including breast pain, tenderness, and nodularity