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Aromatic organic compounds that consist of a phenyl functional group (−C6H5) bonded to a hydroxyl functional group (−OH). Includes all compounds that do not have additional substitutions.
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L-690 330 (CAS 142523-38-4) is a competitive inhibitor of inositol monophosphatase (IMPase) exhibiting a Ki between 0 2 and 2 M depending on the enzyme source IMPase catalyzes the hydrolysis of inositol monophosphates yielding free inositol for phosphatidylinositol (PI) cycle signaling In M1 CHO cells L-690 330 did not elevate [3H]InsP1 levels alone but attenuated carbachol-stimulated increases producing effects up to 40% of those observed with lithium In vivo L-690 330 administration led to significant Ins(1)P accumulation in mouse brain following muscarinic agonist stimulation These properties make L-690 330 a valuable tool for probing inositol signaling pathways and studying IMPase-related neurological processes
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