Saturated hydrocarbons
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Medchemexpress LLC Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, (t-4)-tetrathioxomolybdate(2-) (2:1) | 649749-10-0 | 98.0% | 432.56 | 100 MG
ATN-224 is an orally active Cu2+/Zn2+-superoxide dismutase 1 (SOD1) inhibitor that inhibits SOD1 activity in endothelial cells in a dose-dependent manner with an IC50 of 17.5 nM.
- Specific and high affinity for copper ions.
- Inhibits the proliferation of HUVEC (IC50=1.4±0.3 μM).
- Inhibits the activity of purified bovine SOD1 with an IC50 of 0.33±0.03 μM.
- SOD1 inhibition is time-dependent, reaching maximal inhibition by depleting copper.
- Inhibits FGF-2-induced ERK1/2 phosphorylation.
- Orally-available inorganic small molecule that inhibits Cu/Zn-SOD1 in endothelial and tumor cells.
- Significantly inhibits angiogenesis in the Matrigel plug model in mice.
- Angiogenesis inhibition occurs independently of copper depletion.
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Medchemexpress LLC Bis(choline)tetrathiomolybdate | 649749-10-0 | 98.0% | 432.56 g/mol | C10H28MoN2O2S4 | 10 MG
ATN-224 (bis(choline)tetrathiomolybdate) is an orally active Cu2+/Zn2+-dependent superoxide dismutase 1 (SOD1) inhibitor used in research to modulate copper-dependent enzymatic activity and angiogenesis. It inhibits SOD1 activity in endothelial and tumor cells and has been characterized in cellular and in vivo models.
- Orally active Cu2+/Zn2+ SOD1 inhibitor with reported IC50 ~17.5 nM in endothelial cells.
- High affinity copper binder, showing selectivity against Ca, Fe, Mg, Zn, and Mn up to 1 mM.
- Inhibits proliferation of HUVEC cells (IC50 ~1.4 μM) and purified SOD1 (IC50 ~0.33 μM after 24 h).
- Time-dependent SOD1 inhibition, reaching maximal effect at ~16 hours.
- Demonstrated inhibition of angiogenesis in Matrigel plug models in mice.