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Medchemexpress LLC Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, (t-4)-tetrathioxomolybdate(2-) (2:1) | 649749-10-0 | 98.0% | 432.56 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY16074100MG

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ATN-224 is an orally active Cu2+/Zn2+-superoxide dismutase 1 (SOD1) inhibitor that inhibits SOD1 activity in endothelial cells in a dose-dependent manner with an IC50 of 17.5 nM.

  • Specific and high affinity for copper ions.
  • Inhibits the proliferation of HUVEC (IC50=1.4±0.3 μM).
  • Inhibits the activity of purified bovine SOD1 with an IC50 of 0.33±0.03 μM.
  • SOD1 inhibition is time-dependent, reaching maximal inhibition by depleting copper.
  • Inhibits FGF-2-induced ERK1/2 phosphorylation.
  • Orally-available inorganic small molecule that inhibits Cu/Zn-SOD1 in endothelial and tumor cells.
  • Significantly inhibits angiogenesis in the Matrigel plug model in mice.
  • Angiogenesis inhibition occurs independently of copper depletion.

Catalog No. 50-003-94423


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