Acrylic acids and derivatives
Medchemexpress LLC Orvepitant maleate | 579475-24-4 | 99.0% | 25 MG
Orvepitant maleate is the maleate salt of an NK-1 receptor antagonist used for research. It is supplied as a powder for in vitro and in vivo studies, with high affinity for human NK-1 (pKi 10.2), DMSO solubility, and recommended cold storage for stability.
- Maleate salt of an NK-1 receptor antagonist.
- High affinity for human NK-1 (pKi 10.2).
- Powder form with DMSO solubility of 30 mg/mL.
- In vivo vehicle examples achieve ≥5 mg/mL clear solutions.
- Powder storage: -20°C (up to 3 years) or 4°C (up to 2 years).
Selleck Chemical LLC Brompheniramine hydrogen maleate S2585-50mg
Brompheniramine hydrogen maleate(Brompheniramine maleate) is a histamine H1 receptors antagonist
Medchemexpress LLC 6-bromopyridin-3-amine | 13534-97-9 | MFCD01646116 | 99.5% | 173.01 g/mol | C5H5BrN2 | 500 G
6-Bromopyridin-3-amine is an organobromine intermediate and biochemical reagent used in organic synthesis and life-science research. It is supplied as a solid (C5H5BrN2) with a molecular weight of 173.01 g/mol and CAS number 13534-97-9. Documentation including a product data sheet, certificate of analysis, and safety data sheet are available to verify lot-specific properties and purity.
Medchemexpress LLC Vicriviroc maleate | 599179-03-0 | MFCD09833218 | >99.91% | 649.70 | 50 MG
Vicriviroc maleate is a potent, selective, oral bioavailable, and central nervous system (CNS) penetrated antagonist of CCR5, with a Ki of 2.5 nM. It also inhibits HIV-1 in peripheral blood mononuclear cells (PBMC).
- Potent and selective CCR5 antagonist.
- Oral bioavailable and CNS penetrated.
- Inhibits HIV-1 in PBMC cells.
- Shows mean IC50 of 0.45 nM and IC90 of 4 nM for a panel of HIV isolates.
- Exhibits weak activity against hERG (IC50, 5.8 μM).
- Inhibits chemotactic response to MIP-1α with IC50 values below 1 nM.
- Suppresses RANTES-induced signaling with a mean IC50 of 4.2 ± 1.3 nM.
- Potently suppresses tested viral isolates with geometric mean EC50s of 0.04-2.3 nM and IC90s of 0.45-18 nM.
- Demonstrates good oral availability in rats and monkeys, with no acute CNS or GI effects at 10 mg/kg dose.
Medchemexpress LLC 1,4-Dicaffeoylquinic acid | 1182-34-9 | 516.45 | 5 MG
1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid compound isolated from Xanthii fructus. It acts as an inhibitor of xanthine oxidase with an IC50 of 7.36 μM and exhibits anti-inflammatory activity by inhibiting the production of TNF-α induced by LPS.
- Isolated from Xanthii fructus.
- Inhibitor of xanthine oxidase (IC50: 7.36 μM).
- Possesses anti-inflammatory activity.
- Inhibits the production of TNF-α induced by LPS.
- No cytotoxicity observed in RAW 264.7 cells at concentrations up to 50 μM.
- Purity: 99.25%.
Medchemexpress LLC 3-pyridinamine, 6-bromo | 13534-97-9 | MFCD01646116 | 99.5% | 173.01 g/mol | C5H5BrN2 | 100 G
6-Bromopyridin-3-amine is a synthetic small-molecule intermediate used in medicinal chemistry and life-science research. It serves as a building block and reagent for the preparation of heterocyclic compounds and for small-molecule synthesis.
- High purity suitable for research (99.5%).
- Molecular weight 173.01 g/mol.
- Chemical formula C5H5BrN2.
- Available in laboratory-scale package sizes, including 100 g.
- Certificate of analysis provided for each lot.
- Useful as a building block in medicinal chemistry and organic synthesis.