Alpha-halocarboxylic acids and derivatives

Organic compounds that contain a carboxyl group bonded to a halogen group in the alpha position; halogen groups consist of one or more halogen atoms (F, Cl, B, I, At). Includes compounds that are derived from alpha-halocarboxylic acids.

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406 – 420 of 577 results

406

Cayman Chemical FAmidine trifluoroacetate sa

A PAD inhibitor (IC50s = 29.5 and 350 µM for PAD1 and PAD3, respectively, in vitro; irreversibly inactivates four PAD subtypes (kinact/KI = 2,800, 380, 170, and 3,000 M-1min-1); cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively)

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407

AdipoGen Rhodamine 6G bis OEAE amide

Chemical. CAS 1173097-69-2. Formula C32H40N4O4 . C4H2F6O4. MW 772.73. Synthetic. Fluorescent labelling.

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408

Cayman Chemical W140 trifluoroacetate salt

An inactive enantiomer of W146; binds weakly to S1P1 (Ki = 4.6 µM for the human receptor); has been used as a negative control in the study of S1P1 receptor signaling

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409

Cayman Chemical FAmidine trifluoroacetate sa

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410

Cayman Chemical AcDEVDCHO trifluoroacetate s

A potent, reversible inhibitor of caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively); also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively)

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411

Cayman Chemical Pentosidine trifluoroacetate

A well-characterized natural advanced glycation end (AGE) that is often used as a biomarker for the production of all AGEs

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412

Sigma Aldrich Fine Chemicals Biosciences Ethyl 5-bromovalerate 98% | 14660-52-7 | MFCD00000266 | 5G

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413

Sigma Aldrich Fine Chemicals Biosciences Iodoacetic Acid | 64-69-7 | MFCD00002685 | 100g

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414

AdipoGen Rhodamine 6G bis AEA amide bis

Chemical. CAS 1173097-37-4. Formula C30H37N5O2 . C4H2F6O4. MW 727.69. Synthetic. Fluorescent labelling.

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415

AdipoGen GE23077 A1 B1

Chemical. CAS 752989-46-1, 752989-45-0752989-44-9. Formula C31H51N9O16, C31H49N9O16. MW 805.8803.8. Isolated from Actinomadura sp. Cyclic heptapeptide antibiotic. Potent and selective inhibitor of bacterial RNA polymerase RNAP. Inhibits Gram-positive Bacillus subtilis and Gram-negative Escherichia coli RNAPs with IC50 ~20nM, whereas it is not active on E. coli DNA polymerase or on eukaryotic wheat germ RNAP II IC50 values >100µM. Even though of its potent activity in vitro on purified bacterial RNAPs, it shows a narrow spectrum of antimicrobial activity in vivo on Gram-positive and Gram-negative bacteria, due to lack of memmbrane permeability. Acts at the level of transcription initiation. Binds directly to the bacterial RNA polymerase RNAP active-center i and i1 nucleotide binding sites, preventing the binding of initiating nucleotides and thereby preventing transcription initiation.

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416

Cayman Chemical CAY10729 trifluoroacetate sa

A tetrazole derivative of Cl-amidine; selectively inhibits PAD1 over PAD2, PAD3, and PAD4 (kinact/KI = 162,200, 60,000, 17,500, and 25,400 M-1min-1 for PAD1-4, respectively)