Organic nitric acids and derivatives
Apexbio Technology LLC Nicorandil 65141-46-0 10mM (in 1mL DMSO)
Nicorandil (CAS 65141-46-0) is a small molecule that acts as a potassium channel opener and an activator of guanylate cyclase By facilitating potassium efflux nicorandil induces membrane hyperpolarization in vascular smooth muscle cells leading to vasodilation Additionally it enhances intracellular cyclic GMP (cGMP) levels through direct stimulation of guanylate cyclase subsequently activating protein kinase G (PKG) The activation of PKG results in downstream phosphorylation events that inhibit contractile processes in smooth muscle Nicorandil is widely used as a tool compound in cardiovascular research particularly in studies investigating angina vasorelaxation and cellular mechanisms of vascular tone regulation
Apexbio Technology LLC Nicorandil 65141-46-0 50mg
Nicorandil (CAS 65141-46-0) is a small molecule that acts as a potassium channel opener and an activator of guanylate cyclase By facilitating potassium efflux nicorandil induces membrane hyperpolarization in vascular smooth muscle cells leading to vasodilation Additionally it enhances intracellular cyclic GMP (cGMP) levels through direct stimulation of guanylate cyclase subsequently activating protein kinase G (PKG) The activation of PKG results in downstream phosphorylation events that inhibit contractile processes in smooth muscle Nicorandil is widely used as a tool compound in cardiovascular research particularly in studies investigating angina vasorelaxation and cellular mechanisms of vascular tone regulation
Medchemexpress LLC Nicorandil | 65141-46-0 | 98.2% | 1 G
Nicorandil is a potent potassium channel activator that targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). This nicotinamide ester exhibits vasodilatory and cardioprotective effects, making it a potential treatment for angina and ischemic heart diseases.
- Potent potassium channel activator
- Targets vascular nucleoside diphosphate-dependent K+ channels
- Targets cardiac ATP-sensitive K+ channels (KATP)
- Exhibits vasodilatory effects
- Exhibits cardioprotective effects
- Potential treatment for angina
- Potential treatment for ischemic heart diseases
- Stimulates guanylate cyclase to increase cyclic GMP (cGMP) formation
- Activates protein kinase G (PKG)
- Leads to smooth muscle relaxation and coronary vasodilation