Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC Nicorandil 65141-46-0 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B21975.1
Nicorandil (CAS 65141-46-0) is a small molecule that acts as a potassium channel opener and an activator of guanylate cyclase By facilitating potassium efflux nicorandil induces membrane hyperpolarization in vascular smooth muscle cells leading to vasodilation Additionally it enhances intracellular cyclic GMP (cGMP) levels through direct stimulation of guanylate cyclase subsequently activating protein kinase G (PKG) The activation of PKG results in downstream phosphorylation events that inhibit contractile processes in smooth muscle Nicorandil is widely used as a tool compound in cardiovascular research particularly in studies investigating angina vasorelaxation and cellular mechanisms of vascular tone regulation
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?