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Organic compounds that consist of phosphonic acid with organic functional group substitutions; includes compounds that are derived from organic phosphonic acids.
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Tiludronate disodium is an orally active bisphosphonate that acts as an osteoregulator. It is used for the research of metabolic bone disorders. This compound is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase and possesses antiresorptive and anti-inflammatory properties.
Orally active bisphosphonate
Acts as an osteoregulator for metabolic bone disorder research
Potent inhibitor of osteoclast vacuolar H(+)-ATPase
Possesses antiresorptive and anti-inflammatory properties
Inhibits proton transport in kidney-derived and osteoclast-derived vesicles
Reduces osteoclast capacity to secrete protons and favors detachment from bone matrix
Prevents decrease in skeletal mass in osteoporosis models
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