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Organic compounds that consist of phosphonic acid with organic functional group substitutions; includes compounds that are derived from organic phosphonic acids.
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m-PEG4-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Molecular weight: 272.23
Formula: C9H21O7P
CAS number: 1872433-62-9
Appearance: Oil
Color: Brown to reddish brown
Solubility: 25 mg/mL (91.83 mM) in DMSO
Purity: 99.36%
Storage (pure form): -20°C for 3 years, 4°C for 2 years
Storage (in solvent): -80°C for 6 months, -20°C for 1 month
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