Organic sulfuric acids and derivatives
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Medchemexpress LLC Colistin (sulfate) | 1264-72-8 | ≥98.0% | C52H98N16O13.2.5H2O4S | 100 MG
Colistin sulfate is a polypeptide antibiotic effective against gram-negative bacteria. It functions by binding to lipopolysaccharides and phospholipids in the outer cell membrane, competitively displacing divalent cations. This leads to a detergent-like mechanism that is bactericidal to gram-negative bacteria. It is characterized by rapid bacterial killing, a narrow spectrum of activity, and slow development of resistance.
- Inhibits gram-negative bacteria
- Binds to lipopolysaccharides and phospholipids
- Displaces divalent cations (calcium and magnesium)
- Bactericidal through a detergent-like mechanism
- Rapid bacterial killing
- Narrow spectrum of activity
- Slow development of resistance
