c-di-AMP (Cyclic diadenylate) sodium is a STING agonist that activates the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. It also functions as a bacterial second messenger, primarily in Gram-positive bacteria, where it regulates cell growth, survival, and virulence, and modulates the host immune response. Furthermore, it acts as a potent mucosal adjuvant, stimulating both humoral and cellular responses.
- Activates the TBK3-IRF3 signaling pathway.
- Triggers the production of type I IFN and TNF.
- Regulates cell growth, survival, and virulence in Gram-positive bacteria.
- Modulates the host immune response.
- Acts as a potent mucosal adjuvant.
- Stimulates both humoral and cellular responses.