Azepines
Medchemexpress LLC Oxcarbazepine | 28721-07-5 | 99.9% | C15H12N2O2 | 1 ML
Oxcarbazepine (GP 47680) is an anti-epileptic agent that functions as a sodium channel blocker. It significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. It exhibits both anti-cancer and anticonvulsant effects.
- Inhibits glioblastoma cell growth with IC50 values of 12.35 μg/mL for U87 cell lines and 9.45 μg/mL for T98 cell lines.
- Protects mice and rats against generalized tonic-clonic seizures induced by electroshock.
- No tolerance to anticonvulsant effect observed in rats treated daily for 4 weeks.
- Functions as a sodium channel blocker.
- Induces apoptosis or G2/M arrest in glioblastoma cell lines.
Medchemexpress LLC Eslicarbazepine acetate | 236395-14-5 | >99.9% | 100 MG
Eslicarbazepine acetate is an antiepileptic agent that acts as a dual inhibitor of β-Secretase and voltage-gated sodium channels. This prodrug is activated to eslicarbazepine, an active metabolite of oxcarbazepine, sharing an identical mechanism of action. It may offer improved tolerability compared to oxcarbazepine due to potentially not producing as high peak levels of (S)-(+)-licarbazepine immediately after dosing.
- Antiepileptic agent
- Dual inhibitor of β-Secretase and voltage-gated sodium channel
- Prodrug for (S)-(+)-licarbazepine
- Purity of 99.92%
- Solid appearance
- White to off-white color
Medchemexpress LLC Carbamazepine 10,11-epoxide | 36507-30-9 | 99.1% | 252.27 | 1 ML
Carbamazepine 10,11-epoxide is an orally active metabolite of Carbamazepine (HY-B0246). Carbamazepine has anticonvulsant effect and can be used for the research of seizures.
- Orally active metabolite
- Anticonvulsant effect
- Suitable for research of seizures
Cayman Chemical CarbamazepIn 10 11-epoxIde 5mg
An active metabolite of carbamazepine; has anticonvulsant activity against maximal electroshock-induced seizures in mice; has been found in wastewater effluent
Apexbio Technology LLC Oxcarbazepine 28721-07-5 10mM (in 1mL DMSO)
Oxcarbazepine (CAS 28721-07-5) is a small molecule that modulates voltage-gated sodium channels a critical target in neuronal excitability studies It impedes the association of [3H]batrachotoxin ([3H]BTX) with sodium channels demonstrating an IC50 of 160 M and restricts sodium ion influx as indicated by inhibition of 22Na uptake into rat brain synaptosomes with an IC50 of approximately 100 M These properties make oxcarbazepine valuable for investigating sodium channel function and regulation in neuropharmacology and for exploring mechanisms underlying neuronal signaling and excitotoxicity
Medchemexpress LLC Oxcarbazepine | 28721-07-5 | 99.9% | 252.27 | C15H12N2O2 | 10 MG
Oxcarbazepine (Standard) is an analytical reference standard of oxcarbazepine supplied for research and analytical applications. It is intended for qualitative, quantitative, and methodological experiments in HPLC, GC, and MS, and is commonly used for method development and assay calibration. CAS 28721-07-5.
- Analytical reference standard for HPLC, GC, and MS.
- High purity (99.88%), suitable for quantitative analysis.
- Available in multiple small package sizes, including 10 mg.
- Supplied with certificate of analysis and safety data sheet.
- Intended for method development, assay calibration, and quality control.
Medchemexpress LLC Carbamazepine-(Ph)d8 | 298-46-4 | 98.7% | 244.32 g/mol | C15H4D8N2O | 10 MG
Deuterium-labeled carbamazepine (phenyl-deuterated, d8) supplied as a small-quantity analytical standard for research use only. It is intended as an internal standard for mass spectrometry, pharmacokinetic studies, and analytical method development; not for human or clinical use.
- Suitable as an internal standard for quantitative mass spectrometry
- High isotopic enrichment and analytical-grade purity
- Reported purity: 98.7%
- Molecular weight: 244.32 g/mol
- Chemical formula: C15H4D8N2O
- Provided as a 10 mg powder for laboratory use
Medchemexpress LLC Carbamazepine 10,11-epoxide | 36507-30-9 | 99.1% | 252.27 | 100 MG
Carbamazepine 10,11-epoxide is an orally active metabolite of Carbamazepine. It has an anticonvulsant effect and can be used for the research of seizures.
- Orally active metabolite
- Has anticonvulsant effect
- Used for research of seizures
- For research use only
- Appearance: Solid, off-white to light yellow
Apexbio Technology LLC Eslicarbazepine acetate 236395-14-5 100mg
Eslicarbazepine acetate (CAS 236395-14-5) is an orally administered anticonvulsant prodrug that undergoes rapid first-pass hydrolysis to yield eslicarbazepine its pharmacologically active metabolite Eslicarbazepine predominantly modulates neuronal excitability by stabilizing the inactivated state of voltage-gated sodium channels thereby reducing sustained repetitive neuronal firing associated with seizure activity While approved for adjunctive treatment in partial-onset seizures eslicarbazepine acetate is frequently utilized in research to investigate the pathophysiology of epileptic disorders and to study sodium channel-mediated neuronal signaling