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Medchemexpress LLC N-cycloheptyl-6,7-dimethoxy-2-(4-piperidin-1-ylpiperidin-1-yl)quinazolin-4-amine | 864289-85-0 | 100.0% | 467.65 g/mol | C27H41N5O2 | 10 MG
C-021 is a small-molecule CCR4 antagonist (CAS 864289-85-0) provided as a high-purity solid for research use. It is intended for in vitro and in vivo pharmacology studies where CCR4 inhibition is required. Supplied quantity: 10 mg; follow recommended solvent and storage guidance when preparing solutions.
- Potent CCR4 antagonist for pharmacological research.
- High purity (99.95%).
- Solid powder form suitable for dissolution in DMSO or ethanol.
- Soluble in DMSO or ethanol at 50 mg/mL (~106.9 mM).
- Powder storage: -20°C for long-term stability; in-solution storage: -80°C recommended.
- CAS number: 864289-85-0.
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Medchemexpress LLC PR5-LL-CM01 | 1005307-86-7 | 98.4% | 401.51 | 50 MG
PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities and demonstrates efficacy in inhibiting cancer cells while showing low toxicity in normal cells.
- Has IC50 values ranging from 2-4 μM in PDAC cells (PANC1, MiaPaCa2, and AsPC1) and 10-11 μM in CRC cells (HT29, HCT116, and DLD1).
- Strongly inhibits colony-forming ability in both PANC1 and HT29 cells.
- Inhibits NF-κB activation and its target gene expression in PDAC and CRC cells.
- Significantly decreases TNFα and IL8 expression in both PANC1 and HT29 cells (at 0-15 μM).
- Shows significant anti-tumor effects in PANC1 and HT29 xenografted mice in vivo (20 mg/kg; i.p.; 3 times per week) without visibly affecting their body weight.