Benzoxazoles

Apexbio Technology LLC A23187, free acid 52665-69-7 10mg

A23187 free acid (CAS 52665-69-7) is a calcium ionophore facilitating Ca transport across biological membranes It is designed to increase intracellular Ca concentration thereby modulating calcium-dependent cellular processes A23187 free acid exerts its biological activity by promoting transmembrane Ca influx In cell-based studies A23187 induces mitochondrial permeability transition and apoptosis in HL-60 cells and stimulates phosphoinositide hydrolysis and inositol release in cultured rat Kupffer cells In rat C6 glioma cells co-treatment with 100 nM A23187 enhances zinc-induced apoptosis with an IC of approximately 1 9 nM correlating with increased intracellular Zn influx Based on these pharmacological properties A23187 free acid holds research potential in studies of apoptosis and calcium or zinc homeostasis