Biotin and derivatives
Medchemexpress LLC DBCO-NHS ester 2 1g | 1384870-47-6 | 1 G
DBCO-NHS ester 2 is a dibenzoazacyclooctyne (DBCO)-containing N-hydroxysuccinimide (NHS) ester reagent for strain-promoted alkyne-azide cycloaddition (SPAAC). It is used to install a DBCO handle on amine-containing molecules for copper-free click conjugation to azide-functionalized partners and as a cleavable linker in bioconjugation workflows.
- Amine-reactive NHS ester for efficient coupling to primary amines.
- DBCO group enables strain-promoted copper-free click chemistry with azides.
- Suitable for bioconjugation and linker formation in antibody-drug conjugates.
- High reported purity for reproducible conjugation performance.
- Supplied as a 1 g quantity for small-scale synthesis and labeling.
Medchemexpress LLC DBCO-NHS ester 2 250mg | 1384870-47-6 | 250 MG
DBCO-NHS ester 2 is a dibenzocyclooctyne-derived N-hydroxysuccinimide (NHS) ester used as an amine-reactive linker for copper-free click chemistry and antibody-drug conjugate synthesis. The activated NHS ester enables rapid conjugation to primary amines, while the DBCO moiety enables strain-promoted azide-alkyne cycloaddition (SPAAC) without copper catalysts.
- Amine-reactive NHS ester for efficient amide bond formation
- Enables strain-promoted azide-alkyne cycloaddition (SPAAC) for copper-free click chemistry
- High purity (99.69%) suitable for bioconjugation applications
- Molecular weight 430.45 Da; formula C25H22N2O5
- Powder form; store at -20°C for long-term stability
- Packaged as a 250 mg solid for laboratory use
Medchemexpress LLC PD-L1 Mouse Biotin 100ug | 100ug
PD-L1 protein serves as a ligand for the inhibitory receptor PDCD1/PD-1 and is critical for maintaining immune tolerance This interaction modulates T cell activation limits effector responses and may stimulate IL10-producing T cell subsets PD-L1 Protein Mouse (Biotinylated HEK293 His) is the recombinant mouse-derived PD-L1 protein expressed by HEK293 with C-His labeled tag
Medchemexpress LLC N-piperidine Ibrutinib hydrochloride | 2231747-18-3 | 98.1% | 50 MG
N-piperidine Ibrutinib hydrochloride is a reversible Ibrutinib derivative and a potent BTK inhibitor. It can be used as a BTK ligand in the synthesis of various PROTACs.
- Potent BTK inhibitor with IC50s of 51.0 nM for WT BTK and 30.7 nM for C481S BTK.
- Can be used as a BTK ligand in the synthesis of PROTACs.
- Enables synthesis of potent PROTAC BTK degraders.
Medchemexpress LLC DOTA-NHS-ester (TFA) | 00-00-0 | MFCD23381190 | 95.0% | 615.51 g·mol⁻¹ | C22H32F3N5O12 | 5 MG
DOTA-NHS-ester TFA is an activated N-hydroxysuccinimide (NHS) ester of the DOTA chelator supplied as the trifluoroacetic acid (TFA) salt. It enables efficient conjugation of the DOTA chelator to amine-containing biomolecules for subsequent radiolabeling and imaging applications such as PET and SPECT.
- Activated NHS ester for rapid conjugation to primary amines.
- TFA salt form improves solubility and handling.
- Facilitates stable metal chelation for radiolabeling.
- Suitable for labeling peptides, proteins, and affibodies.
- Available in small-scale research quantities for preclinical work.