Biotin and derivatives
Medchemexpress LLC Bis-PEG13-NHS ester | 2221949-00-2 | 98.0% | 884.92 g/mol | C38H64N2O21 | 25 MG
Bis-PEG13-NHS ester is a PEG-based N-hydroxysuccinimide (NHS) ester linker for research use in the synthesis of antibody-drug conjugates (ADCs) and proteolysis targeting chimeras (PROTACs).
- Provides a bifunctional PEG13 spacer for conjugation to amines.
- Reactive NHS ester termini enable efficient coupling.
- High purity suitable for research applications.
- Molecular weight approximately 884.92 g/mol; molecular formula C38H64N2O21.
- Available in small pack sizes for research-scale synthesis.
Medchemexpress LLC Mal-PEG8-NHS ester | 2055033-05-9 | 98.96% | 25 MG
Mal-PEG8-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound is for research use only and aids in the development of PROTACs, which exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Biotin-PEG3-iodoacetamide | 2306161-26-0 | 97.0% | 10 MG
Biotin-PEG3-iodoacetamide is a PEG-based linker combining a biotin tag, a three-unit PEG spacer, and an iodoacetamide reactive group. It selectively alkylates cysteine residues under mild conditions to introduce a biotin handle for affinity capture, detection, and enrichment workflows.
- Selective cysteine labeling via iodoacetamide chemistry.
- Biotin tag enables high-affinity streptavidin capture.
- PEG3 spacer improves solubility and reduces steric hindrance.
- Suitable for protein labeling, pull-downs, and detection assays.
- Provided as a small-molecule reagent for research use.
Medchemexpress LLC DOTA-NHS-ester | 170908-81-3 | >97.0% | 501.49 g/mol | C20H31N5O10 | 250 MG
DOTA-NHS-ester is an NHS-activated DOTA chelator used to conjugate the DOTA moiety to biomolecules (for example, peptides, proteins, and affibodies) to enable radiolabeling for PET, SPECT, and radiotherapeutic research. It is supplied as a white to off-white solid with high purity and is soluble in DMSO.
- NHS-activated DOTA chelator for amine conjugation.
- High purity (>97.0%).
- Molecular weight 501.49 g/mol; formula C20H31N5O10.
- Soluble in DMSO (50 mg/mL); ultrasonic assistance recommended.
- Storage: sealed, away from moisture; in solvent -80°C (6 months) or -20°C (1 month).
- Intended for radiolabeling research (PET/SPECT); not for human use.
Medchemexpress LLC TCO-PEG12-NHS ester | 2185016-39-9 | MFCD00012569 | 95.0% | 866.99 | C40H70N2O18 | 10 MG
TCO-PEG12-NHS ester is a PEG-based linker reagent consisting of a trans-cyclooctene (TCO) group connected through a 12-unit polyethylene glycol (PEG12) spacer to an N-hydroxysuccinimide (NHS) ester. It enables efficient amine coupling and rapid tetrazine click chemistry, and is used as a cleavable linker in ADC and PROTAC synthesis for bioconjugation applications.
- Provides a TCO functional group for rapid click reactions.
- PEG12 spacer improves solubility and reduces steric hindrance.
- NHS ester enables efficient coupling to primary amines.
- Suitable for ADC and PROTAC linker construction and general bioconjugation.
- Supplied in small research-scale quantities for conjugation workflows.
Medchemexpress LLC Biotin-PEG1-azide | 1204085-48-2 | 99.9% | 356.44 | C14H24N6O3S | 25 MG
Biotin-PEG1-azide is a biotinylated, single-unit polyethylene glycol (PEG) linker terminating in an azide functional group. It is used for bioconjugation and antibody-drug conjugate (ADC) synthesis through click chemistry reactions (CuAAC and SPAAC).
- Cleavable single-unit PEG linker for controlled spacing and solubility.
- Azide functional group enables CuAAC with alkynes and strain-promoted cycloaddition with DBCO/BCN.
- Suitable for ADC synthesis, protein labeling, and bioconjugation workflows.
- High purity (99.9%), characterized by H NMR, RP-HPLC, and MS.
- Available in small-scale packs for research use (e.g., 25 mg).
Medchemexpress LLC Bis-PEG13-NHS ester | 2221949-00-2 | MFCD21363287 | 98.0% | 884.92 | C38H64N2O21 | 50 MG
Bis-PEG13-NHS ester is a bifunctional PEG-based linker containing N-hydroxysuccinimide (NHS) ester reactive groups that enable efficient amine conjugation; it is used as a cleavable linker in antibody-drug conjugate and PROTAC synthesis and for general bioconjugation chemistry.
- contains N-hydroxysuccinimide (NHS) ester reactive groups.
- functions as a cleavable linker for ADC and PROTAC synthesis.
- molecular formula C38H64N2O21, molecular weight 884.92.
- cas number 2221949-00-2 for unambiguous identification.
- purity 98.0% suitable for research applications.
- available in a 50 MG pack suitable for lab-scale synthesis.
- intended for research use only; not for human or clinical use.
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine conjugated to biotin | 133695-76-8 | MFCD01961045 | 97.5% | 974.36 | C51H96N3O10PS | 50 MG
DSPE-Biotin is a biotinylated phospholipid used as a lipid reagent for biochemical research, liposome formulation, and surface functionalization of nanoparticles. It enables biotin-mediated capture or labeling of lipid assemblies and supports drug-delivery and biochemical assay applications. Store cold and protect from light for best stability.
- Biotinylated phospholipid enabling strong biotin-avidin interactions.
- Suitable for liposome preparation and nanoparticle surface functionalization.
- Facilitates biotin-mediated capture and labeling of lipid assemblies.
- High purity (97.5%) for reproducible experimental results.
- Solid, off-white to light yellow appearance for easy handling.
- Storage: -20°C; in solvent: -80°C (6 months), -20°C (1 month); protect from light.
Medchemexpress LLC Mal-GGG-Bal-NHS ester | 1193111-65-7 | 97.6% | 522.47 g/mol | 5 MG
Mal-GGG-Bal-NHS ester is an ADC linker reagent used to introduce a maleimide-containing GGG-Bal-NHS moiety for conjugation to antibodies or other amine- or thiol-containing biomolecules.
- Used as an ADC linker in antibody-drug conjugate synthesis.
- Contains an NHS ester for amine coupling and a maleimide for thiol conjugation.
- High reported purity of 97.6% for reliable coupling performance.
- Soluble in water at high concentration (50 mg/mL) with ultrasonic treatment if needed.
- Recommended storage under inert atmosphere and cold conditions to preserve stability.
Medchemexpress LLC FP-Biotin | 259270-28-5 | 99.1% | 592.75 | 25 MG
FP-biotin is a potent organophosphorus toxicant, well-suited for searching for new biomarkers of organophosphorus toxicants exposure. It quantifies FAAH, ABHD6, and MAG-lipase activity. FP-biotin is also used for studies with plasma because biotinylated peptides are readily purified by binding to immobilized avidin beads. In vitro, it shows good reactivity with human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), making it appropriate for identifying organophosphorus toxicants reactive proteins.
- Potent organophosphorus toxicant
- Suitable for identifying new biomarkers of organophosphorus toxicant exposure
- Quantifies FAAH, ABHD6, and MAG-lipase activity
- Used in plasma studies for easy purification of biotinylated peptides
- Exhibits good reactivity with human AChE and BChE
- Appropriate for identifying organophosphorus toxicant-reactive proteins
Medchemexpress LLC m-PEG-NHS ester | 92451-01-9 | MFCD06412227 | 90.0% | 350 g/mol | (C2H4O)nC7H9NO5 | 10 MG
m-PEG-NHS ester (MW 350) is a methoxy-terminated polyethylene glycol activated as an N-hydroxysuccinimide (NHS) ester for covalent PEGylation of primary amine-containing molecules. It is intended to improve solubility and stability, reduce immunogenicity, and enable bioconjugation and surface functionalization in research applications.
- Activated NHS ester for efficient coupling to primary amines.
- Methoxy termination prevents crosslinking and limits multi-attachment.
- Improves solubility and stability of biomolecules.
- Reduces immunogenicity and can extend circulation half-life.
- Suitable for protein, peptide, and small-molecule PEGylation.
- Available in small mg-scale quantities for research use.