Biotin and derivatives
D-Biotin, MP Biomedicals™
CAS: 58-85-5 Molecular Formula: C10H16N2O3S Molecular Weight (g/mol): 244.31 MDL Number: MFCD00005541 InChI Key: YBJHBAHKTGYVGT-UHFFFAOYNA-N Synonym: biotin,d-biotin,vitamin h,coenzyme r,vitamin b7,bios ii,factor s,bioepiderm,d +-biotin,biodermatin PubChem CID: 171548 ChEBI: CHEBI:15956 IUPAC Name: 5-{2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl}pentanoic acid SMILES: OC(=O)CCCCC1SCC2NC(=O)NC12
D-Biotin, MP Biomedicals
CAS: 58-85-5 Molecular Formula: C10H16N2O3S Molecular Weight (g/mol): 244.31 MDL Number: MFCD00005541 InChI Key: YBJHBAHKTGYVGT-UHFFFAOYNA-N Synonym: biotin,d-biotin,vitamin h,coenzyme r,vitamin b7,bios ii,factor s,bioepiderm,d +-biotin,biodermatin PubChem CID: 171548 ChEBI: CHEBI:15956 IUPAC Name: 5-{2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl}pentanoic acid SMILES: OC(=O)CCCCC1SCC2NC(=O)NC12
Thermo Scientific Chemicals D(+)-Biotin, 98%
CAS: 58-85-5 Molecular Formula: C10H16N2O3S Molecular Weight (g/mol): 244.31 MDL Number: MFCD00005541 InChI Key: YBJHBAHKTGYVGT-UHFFFAOYNA-N Synonym: biotin,d-biotin,vitamin h,coenzyme r,vitamin b7,bios ii,factor s,bioepiderm,d +-biotin,biodermatin PubChem CID: 171548 ChEBI: CHEBI:15956 IUPAC Name: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid SMILES: OC(=O)CCCCC1SCC2NC(=O)NC12
Biotin, Powder, FCC, 97.5-100.5%, Spectrum™ Chemical
CAS: 58-85-5 Molecular Formula: C10H16N2O3S Molecular Weight (g/mol): 244.31 MDL Number: MFCD00005541 InChI Key: YBJHBAHKTGYVGT-UHFFFAOYNA-N IUPAC Name: 5-{2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl}pentanoic acid SMILES: OC(=O)CCCCC1SCC2NC(=O)NC12
Biotin, Powder, USP, 97.5-102%, Spectrum™ Chemical
CAS: 58-85-5 Molecular Formula: C10H16N2O3S Molecular Weight (g/mol): 244.31 MDL Number: MFCD00005541 InChI Key: YBJHBAHKTGYVGT-UHFFFAOYNA-N IUPAC Name: 5-{2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl}pentanoic acid SMILES: OC(=O)CCCCC1SCC2NC(=O)NC12
Medchemexpress LLC Biotin-azide | 908007-17-0 | 99.84% | 500 MG
Biotin-azide is a form of biotin with a terminal azide group, designed for Click Chemistry applications. It enables the preparation of various biotinylated conjugates through copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This reagent has been used in vitro for post-crosslinking chemical functionalization to isolate transcriptional protein complexes from yeast cells.
- Used in Click Chemistry to prepare biotinylated conjugates.
- Facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions.
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
- Applied in post-crosslinking chemical functionalization to isolate transcriptional protein complexes.
Medchemexpress LLC (+)-Biotin-SLC | 1864003-57-5 | ≥97.0% | 500 MG
(+)-Biotin-SLC is an alkyl chain-based PROTAC linker. It can be used in the synthesis of PROTACs, which are designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs exploit the intracellular ubiquitin-proteasome system
- PROTACs selectively degrade target proteins
- For research use only
Medchemexpress LLC (+)-Biotin 4-nitrophenyl ester | 33755-53-2 | ≥98.0% | 500 MG
(+)-Biotin-ONP is an alkyl chain-based PROTAC linker that can be utilized in the synthesis of PROTACs. This mechanism leverages the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PROTACs consist of two distinct ligands connected by a linker.
- One ligand targets an E3 ubiquitin ligase.
- The other ligand targets the protein intended for degradation.
Medchemexpress LLC Bis-PEG21-NHS ester | 2221948-98-5 | 99.9% | 500 MG
Bis-PEG21-NHS ester is a PEG/Alkyl/ether-based PROTAC linker primarily used in the synthesis of PROTACs. It also serves as a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).
- PEG/Alkyl/ether-based linker
- PROTAC linker for targeted protein degradation
- Cleavable ADC linker
- Utilizes the ubiquitin-proteasome system
- Suitable for PROTACs synthesis
- Suitable for ADC synthesis
Medchemexpress LLC Biotin-DADOO (Biotinyl-3,6-dioxaoctanediamine) | 138529-46-1 | 98.0% | 500 MG
Biotin-DADOO is a biotin-containing amine compound and a biotinylation reagent. It acts as an amino component in the nucleophilic ring-opening reaction of epoxidized ω-double bonds during the synthesis of biotinylated inhibitor derivatives. This product can be conjugated with carboxymethyl cellulose derivatives and is involved in the synthesis of biotin-estradiol conjugates for enzyme immunoassays. It can also be utilized in influenza A research.
- Captures free influenza neuraminidase on streptavidin-coated polystyrene plates.
- Forms stable self-assembled monolayers (SAMs) on planar gold surfaces.
- Forms a stable biotin-estradiol conjugate.
Medchemexpress LLC DOTA-NHS-ester | 170908-81-3 | MFCD23381190 | >97.0% | 501.49 | C20H31N5O10 | 500 MG
DOTA-NHS-ester is a bifunctional chelator containing a DOTA macrocycle and an N-hydroxysuccinimide (NHS) ester. It enables covalent conjugation to amine-containing biomolecules and subsequent radiometal chelation for imaging or radiotherapy research applications.
- Bifunctional chelator with NHS-ester for amine conjugation.
- High purity (≥97.0%) solid suitable for research.
- Molecular weight 501.49 and formula C20H31N5O10.
- Soluble in DMSO (50 mg/mL) and compatible with common in vivo formulations.
- Store powder at -20°C; solutions at -80°C (6 months) or -20°C (1 month).
- Available in a 500 mg pack size.
Medchemexpress LLC Bis-PEG9-NHS ester 500mg | 1008402-79-6 | 708.71 | C30H48N2O17 | 500 MG
Bis-PEG9-NHS ester is a PEG9-based bifunctional linker bearing two N-hydroxysuccinimide (NHS) ester groups, designed for amine-targeted bioconjugation and linker applications such as PROTAC and ADC synthesis. It provides a hydrophilic spacer to improve solubility and reduce aggregation during conjugation.
- Bifunctional amine-reactive crosslinker with two NHS ester groups.
- PEG9 spacer increases hydrophilicity and solubility in aqueous media.
- Suitable for PROTAC, ADC, and general bioconjugation to primary amines.
- High chemical purity (≥98%) for reliable conjugation performance.
- Viscous, colorless to light yellow material; moisture sensitive - store sealed and protected from moisture.
- Molecular weight ≈ 708.71 g/mol; molecular formula C30H48N2O17.
Medchemexpress LLC DBCO-NHS ester 2 500mg | 1384870-47-6 | 430.45 | C25H22N2O5 | 500 MG
DBCO-NHS ester 2 is a dibenzylcyclooctyne (DBCO)-derived N-hydroxysuccinimide (NHS) ester used as an amine-reactive linker for bioconjugation and antibody-drug conjugate synthesis. The reagent enables copper-free click chemistry via strain-promoted alkyne-azide cycloaddition (SPAAC) and is supplied as a powder for laboratory use.
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) for copper-free click chemistry.
- Amine-reactive NHS ester for efficient labeling of proteins, peptides, and small molecules.
- Appropriate for antibody-drug conjugate (ADC) linker synthesis and general bioconjugation.
- High reported purity in product documentation.
- Powder form with long-term storage at -20°C; soluble in DMSO (≈14.29 mg/mL) with ultrasonic assistance.
Medchemexpress LLC Biotin hydrazide | 66640-86-6 | MFCD00078532 | 98.7% | 258.34 g·mol⁻¹ | C10H18N4O2S | 500 MG
Biotin hydrazide is a carbonyl-reactive biotinylation reagent used to label carbonyl-containing biomolecules. It reacts with aldehyde and ketone groups (for example, periodate-oxidized glycoproteins) to introduce a biotin tag for downstream detection, affinity capture, and streptavidin-based assays.
- Reacts with carbonyl groups for selective biotinylation.
- Enables streptavidin-based detection and affinity capture.
- High purity for reproducible biochemical assays.
- Available as solid and solution preparations for workflow flexibility.
- Suitable for protein labeling and probe-based detection applications.
Medchemexpress LLC Boc-NH-PEG2-C2-NHS ester | 2183440-73-3 | ≥98.0% | C16H26N2O8 | 500 MG
Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-based PROTAC linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs). PROTACs are compounds designed to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins, functioning by connecting two ligands: one for an E3 ubiquitin ligase and one for the target protein. This compound appears as a white to off-white solid.
- Alkyl/ether-based PROTAC linker
- Used in the synthesis of PROTACs
- Enables selective degradation of target proteins
- Appears as a white to off-white solid
- For research use only
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