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Cefotetan is a binding agent that targets human Raf1 kinase inhibitor protein (hRKIP), enhancing ERK phosphorylation by relieving hRKIP's inhibition of the Ras/Raf1/MEK/ERK signaling pathway. It is also a broad-spectrum antibacterial agent that disrupts cell wall synthesis by binding to bacterial penicillin-binding proteins (PBPs). Cefotetan is used to study diseases associated with dysregulated Ras/Raf1/MEK/ERK signaling pathways and bacterial infections.
Targets human Raf1 kinase inhibitor protein (hRKIP).
Enhances ERK phosphorylation.
Broad-spectrum antibacterial activity.
Disrupts bacterial cell wall synthesis.
Effective against Gram-positive and Gram-negative bacteria.
Highly stable against β-lactamases.
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