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Medchemexpress LLC SB 204990 | 154566-12-8 | 99.8% | 389.27 | 100 MG
SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme. It is for research use only. SB 204990 treatment leads to a decrease in cytosolic Ac-CoA levels, which is expected to decrease acetylated and active β-catenin levels. When administered orally to rats, it is absorbed into the systemic circulation, causing a dose-related decrease in plasma cholesterol and triglyceride levels. In dogs, it also decreases plasma cholesterol and triglyceride levels, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels.
- Potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.
- Decreases cytosolic Ac-CoA levels.
- Reduces acetylated and active β-catenin levels.
- Decreases plasma cholesterol and triglyceride levels in rats and dogs.
- Preferentially decreases low-density lipoprotein compared with high-density lipoprotein cholesterol levels in dogs.
