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Organic compounds that contain one or more heterocycles that are aromatic; heterocycles are rings that contain atoms from two or more types of elements.
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CbzNH-PEG3-CH2CH2NH2 is a Cbz-protected PEG3 amine linker (benzyl N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]carbamate) used as a hydrophilic spacer in bioconjugation. It provides a terminal primary amine for conjugation while the carbobenzyloxy (Cbz) group protects the opposing amine during multistep synthesis. Common applications include linker design for PROTACs, peptide and small-molecule conjugation, and other bioconjugation workflows.
Provides a hydrophilic PEG3 spacer to improve aqueous solubility.
Contains a terminal primary amine for standard coupling reactions.
Includes a Cbz protecting group for orthogonal amine protection.
Available in research-scale quantities suitable for synthesis and screening.
Typically supplied with high reported purity; consult the batch COA for exact value.
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Benzyl N-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethyl)carbamate is a Cbz-protected PEG3 linker bearing a terminal primary amine. The hydrophilic PEG spacer improves aqueous solubility, while the Cbz protecting group enables controlled deprotection, making the reagent useful for installing amine-functional linkers in small-molecule conjugates, bioconjugation workflows, and PROTAC assemblies.
Cbz-protected terminal amine for orthogonal deprotection.
PEG3 spacer increases water solubility.
Primary amine handle for reliable conjugation chemistry.
Compatible with linker synthesis and bioconjugation workflows.
Available in laboratory-scale quantities for synthesis and screening.
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CbzNH-PEG3-CH2CH2NH2 is a Cbz-protected polyethylene glycol (PEG3) linker with a terminal primary amine. It is supplied as a research building block for organic synthesis and bioconjugation workflows where a short, hydrophilic spacer and a protected amine are required for stepwise coupling and modification.
Cbz-protected primary amine for orthogonal deprotection.
PEG3 spacer provides hydrophilicity and flexibility.
Suitable for linker and conjugate synthesis in medicinal chemistry.
Available in small milligram-to-gram quantities for research use.
Reported high purity appropriate for synthetic applications.
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Nilotinib (AMN-107 CAS 641571-10-0) is an orally bioavailable selective inhibitor targeting the BCR-ABL tyrosine kinase Derived structurally from imatinib nilotinib inhibits both wild-type (WT p210) and mutant forms (E281K E292K F317L M351T F486S) of BCR-ABL reducing their autophosphorylation activity with IC50 values ranging from 20 to 42 nM It also exhibits substantial inhibitory activity against activated KIT mutants (e g V560del K642E) and various KIT double mutations and effectively suppresses PDGFR and PDGFR kinases Nilotinib is utilized extensively in research related to chronic myeloid leukemia and gastrointestinal stromal tumors involving kinase-driven pathologies
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