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Organic heterocyclic compounds that contain an imidazole ring fused to a pyridine ring. Imidazole is five-membered ring with three carbon atoms and two nitrogen atoms; pyridine is a six-membered ring with five carbon atoms and one nitrogen atom.
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Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. It induces regression of Tamoxifen-resistant, hormone independent xenograft tumors.
Orally active and selective estrogen receptor modulator (SERM).
Induces regression of Tamoxifen-resistant, hormone independent xenograft tumors.
Inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation at 100 nM for 10 days.
Significantly inhibits the growth of MCF-7:5C cells and induces apoptosis at 100 nM for 9 days.
Appearance: Solid, White to off-white.
Shipping: Room temperature in continental US; may vary elsewhere.
Storage: Powder at -20°C for 3 years; In solvent at -80°C for 6 months, or -20°C for 1 month.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
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