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Organic heterocyclic compounds that contain an imidazole ring fused to a pyrimidine ring. Imidazole is five-membered ring with three carbon atoms and two nitrogen atoms; pyrimidine is a six-membered ring with four carbon atoms and two nitrogen atoms.
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Xanthine is synthesized from guanine in the presence of guanine deaminase. Xanthine oxidase catalyzes the production of xanthine from hypoxanthine and its subsequent breakdown to uric acid. Xanthine derivatives are present in coffee tea and cocoa seeds. Xanthine has been proposed as a lead for the generation of pharmacologically active compounds.
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Theobromine (CAS 83-67-0) is a methylxanthine alkaloid predominantly present in cocoa beans and consequently in chocolate products with concentrations highest in dark chocolate It functions primarily as a non-selective phosphodiesterase inhibitor and adenosine receptor antagonist leading to increased intracellular cyclic AMP levels and mild central nervous system stimulation Theobromine s pharmacological actions include diuretic bronchodilatory and vasodilatory effects Due to these properties it is utilized in research on cardiovascular and respiratory physiology as well as studies on methylxanthine-related cellular signaling pathways and metabolism
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Theophylline (CAS 58-55-9) is a methylxanthine alkaloid originally isolated from tea leaves It functions primarily as a nonselective phosphodiesterase inhibitor leading to increased intracellular cyclic AMP levels and acts as an adenosine receptor antagonist These mechanisms underlie its bronchodilatory cardiac stimulant and mild diuretic properties Theophylline is soluble in water ethanol chloroform alkali ammonia water and diluted acids In biomedical research it is utilized to study airway smooth muscle relaxation cardiac physiology and signaling pathways involving cyclic nucleotides The compound should be stored in a tightly sealed container in a cool dry environment
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