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Potassium 1H-indol-3-yl sulfate is a tryptophan metabolite produced by intestinal microorganisms and sulfated in the liver before entering circulation. It acts as a potent endogenous agonist of the aryl hydrocarbon receptor (AhR) and is identified as a urinary toxin.
Used for research on kidney diseases
Significantly induces mRNA expression of CYP1A1/1A2/1B1 and UGT1A1/1A6
Regulates immune/inflammatory-related genes by continuously activating AHR
Exhibits plasma levels highly dependent on a healthy gut microbiota
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