Indoles and derivatives
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eMolecules Pharmablock (2S)-2-cyclopropyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)acetic acid 25mg 788493701 PBA0394 0 000 1212257-18-5 MFCD06659145 337 375 C20H19NO4
Pharmablock (2S)-2-cyclopropyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)acetic acid 25mg 788493701 PBA0394 0 000 1212257-18-5 MFCD06659145 337 375 C20H19NO4
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eMolecules Pharmablock (2S)-2-cyclopropyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)acetic acid 50mg 788493702 PBA0394 0 000 1212257-18-5 MFCD06659145 337 375 C20H19NO4
Pharmablock (2S)-2-cyclopropyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)acetic acid 50mg 788493702 PBA0394 0 000 1212257-18-5 MFCD06659145 337 375 C20H19NO4
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Medchemexpress LLC Indomethacin sodium hydrate | 74252-25-8 | MFCD00227184 | 99.85% | 10 MM * 1 ML in DMSO
Indomethacin sodium hydrate is an orally active and BBB-permeable COX1/2 inhibitor, demonstrating IC50 values of 18 nM for COX-1 and 26 nM for COX-2. It exhibits both anticancer and anti-infective activities, making it suitable for research in cancer, inflammation, and viral infections.
- In vitro studies show Indomethacin sodium hydrate (0-150 μM; 24 hours; 3LL-D122 cells) possesses anticancer activity.
- It protects host cells from virus-induced damage by activating PKR, which results in eIF2α phosphorylation.
- This mechanism leads to the inhibition of viral protein translation and replication, with an IC50 of 2 μM.