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Medchemexpress LLC Indomethacin sodium hydrate | 74252-25-8 | MFCD00227184 | 99.85% | 10 MM * 1 ML in DMSO
SDP

Supplier:  Medchemexpress LLC HY14397A10MM/1ML

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Indomethacin sodium hydrate is an orally active and BBB-permeable COX1/2 inhibitor, demonstrating IC50 values of 18 nM for COX-1 and 26 nM for COX-2. It exhibits both anticancer and anti-infective activities, making it suitable for research in cancer, inflammation, and viral infections.

  • In vitro studies show Indomethacin sodium hydrate (0-150 μM; 24 hours; 3LL-D122 cells) possesses anticancer activity.
  • It protects host cells from virus-induced damage by activating PKR, which results in eIF2α phosphorylation.
  • This mechanism leads to the inhibition of viral protein translation and replication, with an IC50 of 2 μM.

Catalog No. 50-003-55600


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