Lactams
Apexbio Technology LLC Thalidomide 50-35-1 200mg
Thalidomide (CAS 50-35-1) is a small-molecule inhibitor targeting the CRBN-DDB1-Cul4A E3 ubiquitin ligase complex It is designed to modulate ubiquitination pathways thereby regulating protein degradation cellular proliferation and immune signaling Thalidomide exerts its biological activity primarily through inhibition of the CRBN-DDB1-Cul4A complex In cell-based studies thalidomide demonstrates inhibitory activity with reported IC50 values ranging from approximately 1 M to 100 M depending on the assay and cell line Based on these pharmacological properties thalidomide holds research potential in the fields of immune regulation angiogenesis inhibition and cancer biology particularly in studies of hematological malignancies such as multiple myeloma
Medchemexpress LLC Thalidomide-NH-C5-NH2 hydrochloride | 2375194-03-7 | 99.9% | 394.85 | 100 MG
Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the thalidomide-based cereblon ligand and a linker used in PROTAC technology. This conjugate exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 100 MG
Thalidomide-O-C8-Boc is a Thalidomide-based Cereblon ligand designed for recruiting CRBN protein. It can be linked to a target protein ligand via a linker to form PROTACs, making it suitable for research use in laboratory chemical manufacturing. This substance is stable under recommended storage conditions and is not classified as a hazardous substance or mixture.
- Used to recruit CRBN protein
- Can be linked to a target protein ligand via a linker to form PROTACs
- Suitable for laboratory chemical manufacturing
- Stable under recommended storage conditions
- Not classified as a hazardous substance or mixture
- Recommended storage temperature: -20°C, stored under nitrogen
- Molecular formula: C26H34N2O7
- Molecular weight: 486.56
- Appearance: Solid, white to off-white
Medchemexpress LLC Thalidomide-O-amido-PEG4-azide | 2411681-89-3 | 99.19% | C25H32N6O10 | 100 MG
Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It also participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs utilizing this linker are engineered to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Click chemistry reagent with Azide group
- Enables CuAAc reactions with alkyne groups
- Facilitates SPAAC reactions with DBCO or BCN groups
- Used in the synthesis of PROTACs
Medchemexpress LLC Thalidomide-O-PEG4-azide | 2380318-57-8 | 98.0% | C23H29N5O9 | 50 MG
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that integrates a Thalidomide-based cereblon ligand with a linker used in PROTAC technology. This compound is intended for research use only.
- Acts as a click chemistry reagent due to its Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups
Medchemexpress LLC Thalidomide-5-PEG3-NH2 hydrochloride | 2761385-81-1 | 97% | 441.86 | 1 MG
Thalidomide-5-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It has an IC 50 of Cereblon.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Used in PROTAC technology
- Solid form
- White to off-white color
Medchemexpress LLC Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride | 2341841-02-7 | 99.3% | 410.81 | 25 MG
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. This compound is suitable for designing PROTACs.
- Incorporates a cereblon (CRBN) ligand for E3 ubiquitin ligase
- Contains a linker
- Suitable for designing PROTACs
- Relevant to cancer targeted therapy, cancer metabolism, and metastasis
- Related to PROTAC research
- Involved in autophagy studies
- Used in apoptosis research
- Applicable to E3 ligase ligand-linker conjugates
Medchemexpress LLC Thalidomide-O-PEG4-azide | 2380318-57-8 | 98.0% | C23H29N5O9 | 25 MG
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is a click chemistry reagent containing an Azide group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. This product is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Contains an Azide group for click chemistry
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Target: Cereblon
Medchemexpress LLC Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc | 1799711-31-1 | 98.4% | C30H42N4O11 | 50 MG
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide based cereblon ligand and a linker. This product can be used for the synthesis of PROTAC BET degrader.
- E3 ligase ligand-linker conjugate
- Thalidomide based cereblon ligand
- PROTAC BET degrader synthesis
- Inhibitor
Medchemexpress LLC Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]- | 2412056-27-8 | 95.0% | C15H13N3O6 | 25 MG
Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk) and functions as a ligand of E3 ligase. This PROTAC leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins, holding potential for researching various diseases, as extracted from patent WO2021170109A1. This product is for research use only.
- Potent and selective inhibitor of tropomyosin receptor kinase (trk)
- Functions as a ligand for E3 ligase
- PROTAC (proteolysis-targeting chimera) technology
- Utilizes the ubiquitin-proteasome system to degrade target proteins
- Potential for researching various diseases
Medchemexpress LLC Thalidomide-5-O-C8-NH2 hydrochloride | 2636798-38-2 | >95.0% | 437.92 g/mol | C21H28ClN3O5 | 10 MG
Thalidomide-5-O-C8-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for research applications. It is used as a recruiting moiety in PROTACs and other E3 ligase-targeting conjugates to facilitate targeted protein degradation and chemical biology studies. Supplied as a white to off-white solid in small laboratory pack sizes, it supports synthetic conjugation through an alkyl linker.
- Serves as a cereblon-recruiting ligand for targeted protein degradation
- Supplied as a hydrochloride salt for improved stability and handling
- Solid form suitable for storage and synthetic manipulation
- Provides an alkyl linker attachment point for PROTAC assembly
- Compatible with standard organic synthesis and conjugation workflows
- Intended for research use in chemical biology and drug discovery
Medchemexpress LLC Thalidomide-1-Me-5-NH2 | 1468761-60-5 | >98.0% | 287.27 g/mol | C14H13N3O4 | 25 MG
Thalidomide-1-Me-5-NH2 is an aminated analogue of thalidomide supplied as a research reagent. It acts as an E3 ligase ligand building block and can be derivatized at its amine for use in PROTAC design; it is not for medical, clinical diagnostic, or food use.
- Aminated thalidomide analogue suitable as an E3 ligase ligand.
- Can be derivatized at the amine for PROTAC and degrader design.
- High purity (>98.0%) appropriate for chemical biology research.
- Molecular formula C14H13N3O4, molecular weight 287.27 g/mol.
- Available in small quantities suitable for synthesis, for example 25 MG sizes.
- Supplied for research use only; not for medical or diagnostic use.
Medchemexpress LLC Thalidomide-1-me,4-oh | 2244568-06-5 | ≥98.0% | 288.26 g·mol-1 | C14H12N2O5 | 100 MG
Thalidomide-1-Me,4-OH is a thalidomide analogue bearing a 4-hydroxy substituent and an N-1 methyl group. It serves as a cereblon/E3 ligase ligand scaffold for research into ubiquitin-mediated proteolysis and is supplied as a solid research reagent.
- Small-molecule cereblon/E3 ligase ligand used in biochemical and cell-based assays
- High purity suitable for research applications
- Powder form with defined storage recommendations for long-term stability
- Includes chemical identifiers for traceability, including CAS and molecular formula
- Applicable for studies of targeted protein degradation and ligand design
Medchemexpress LLC 5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | 26166-92-7 | MFCD30188073 | 98.4% | 337.13 | C13H9BrN2O4 | 100 MG
Thalidomide-5-Br is a brominated thalidomide derivative supplied for research use in studies of inflammation, tumor biology, and neurology. It is provided as a solid research reagent; consult lot-specific documentation for analytical details.
- Contains a bromodomain; used as a tool compound in biochemical and pharmacological research.
- Reported purity approximately 98% (see product documentation for lot-specific certificate of analysis).
- Solid, off-white to gray appearance suitable for analytical and synthetic applications.
- Storage recommendations: room temperature for shipping; in solution store at -80°C (2 years) or -20°C (1 year).
- Available in multiple pack sizes including 100 mg.
Medchemexpress LLC VH 101 phenol-alkylC4-amine dihydrochloride | 2564467-03-2 | >95.0% | 676.67 g/mol | C30H44Cl2FN5O5S | 5 MG
VH 101 phenol-alkylC4-amine dihydrochloride is a functionalized von Hippel-Lindau (VHL) E3 ligase ligand supplied as the dihydrochloride salt. It is designed as a building block for PROTAC (proteolysis-targeting chimera) synthesis and degrader design, offering a linker-equipped ligand with a terminal amine for conjugation and medicinal chemistry applications.
- Functionalized VHL ligand for PROTAC synthesis.
- Dihydrochloride salt for improved stability and handling.
- Terminal amine compatible with common coupling chemistries.
- Alkyl C4 linker suitable for assembling bifunctional degraders.
- Available in small milligram quantities for medicinal chemistry research.