Lactams
Medchemexpress LLC Thalidomide-5-O-C13-NH2 hydrochloride | 99.9% | 508.05 g/mol | C26H38ClN3O5 | 10 MG
Thalidomide-5-O-C13-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for research use in targeted protein degradation. It is intended for conjugation to target-binding ligands via linkers for PROTAC design and other bifunctional degrader constructs.
- High purity suitable for research assays (approximately 99.9%).
- Hydrochloride salt form for improved stability and handling.
- Compatible with linker conjugation for PROTAC synthesis.
- Recommended storage at -20°C; protect from light and oxygen.
- Supplied in small milligram quantities for exploratory studies.
Medchemexpress LLC Thalidomide-4-OH | 5054-59-1 | MFCD03699892 | 99.9% | 274.23 g·mol⁻¹ | C13H10N2O5 | 10 G
Thalidomide-4-OH is a 4-hydroxylated metabolite of thalidomide used as a Cereblon (CRBN) ligand in chemical biology and PROTAC research. It is supplied as a high-purity solid for synthetic and biochemical applications, with recommended storage under inert atmosphere.
- High purity suitable for synthesis and assays.
- Molecular formula C13H10N2O5; molecular weight 274.23 g·mol⁻¹.
- Used as a CRBN ligand for recruitment of cereblon in PROTACs.
- Available in gram-scale quantities for research workflows.
- Solid with melting point 273-275 °C.
- Recommended storage: 4 °C under nitrogen; in solvent: -80 °C (6 months) or -20 °C (1 month).
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 TFA | 1957236-21-3 | 99.6% | 620.53 g/mol | C25H31F3N4O11 | 10 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a thalidomide-based cereblon ligand-linker conjugate (trifluoroacetic acid salt) designed as a building block for PROTAC synthesis. It links a thalidomide-derived E3 ligase ligand to a three-unit PEG spacer terminating in a C2 amino handle, enabling attachment to targeting ligands and facilitating cereblon-mediated target degradation.
- Thalidomide-based cereblon ligand for E3 ligase recruitment.
- Three-unit PEG linker providing flexible spacing and solubility.
- C2 amino terminal suitable for amide or urea coupling.
- Trifluoroacetic acid salt form for improved handling and stability.
- Molecular formula C25H31F3N4O11; molecular weight 620.53 g/mol.
- Soluble in DMSO at 50 mg/mL; ultrasonic may be required.
- Recommended storage: 4°C sealed; in solvent store at -80°C (6 months) or -20°C (1 month).
- Available in small research quantities suitable for synthesis, e.g., 10 mg.
Medchemexpress LLC Thalidomide-O-amido-C4-N3 | 2098488-36-7 | MFCD31560486 | 98.4% | 428.40 g/mol | C19H20N6O6 | 10 MG
Thalidomide-O-amido-C4-N3 is a thalidomide-derived cereblon ligand-linker conjugate used as a building block in proteolysis-targeting chimera (PROTAC) and E3 ligase ligand research. It is provided with analytical characterization and storage guidance for research applications.
- Used as a cereblon ligand-linker conjugate for PROTAC and E3 ligase research.
- Molecular formula C19H20N6O6; molecular weight 428.40 g/mol.
- CAS number 2098488-36-7 for unambiguous identification.
- Purity 98.4% by LCMS (as supplied).
- Supplied in small research quantities (for example, 10 mg) and as stock solution preparations.
- Soluble in DMSO and compatible solvent systems for formulation.
- Store at 4°C under nitrogen; in solution, store at -80°C (6 months) or -20°C (1 month).
Selleck Chemical LLC Thalidomide-O-COOH
Thalidomide-O-COOH (Cereblon ligand 3 E3 ligase Ligand 3) a Thalidomide-based Cereblon (CRBN) ligand is used in the recruitment of CRBN protein Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs (Proteolysis Targeting Chimera)
Medchemexpress LLC Thalidomide-piperazine 5-fluoride hydrochloride | 2222114-23-8 | MFCD32203462 | 98.9% | 396.80 g/mol | C17H18ClFN4O4 | 1 G
Thalidomide-piperazine 5-fluoride hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as a hydrochloride salt for use in PROTAC synthesis and related cereblon-targeted chemical biology research. It is intended for research use and is provided with documented purity and stability data for handling and storage.
- Thalidomide-based cereblon ligand for PROTAC synthesis.
- Hydrochloride salt form for improved handling and solubility.
- High purity suitable for synthetic and analytical workflows.
- Documented stability under cold storage conditions.
- Provided in a small-scale research package for medicinal chemistry.
Abcam (R,S)-Lenalidomide, Thalidomide analog, TNF alpha inhibitor, 100MG
MW 259.26 Da, Purity >98%. Thalidomide (ab120032) analog and TNF-α inhibitor. Potent antitumor and anti-inflammatory effects. Modulates and potentiates host immune responses against multiple myeloma. Active in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Thalidomide-NH-C10-NH2 hydrochloride | 2460022-53-9 | 464.99 | C23H33ClN4O4 | 10 MG
Thalidomide-NH-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as a hydrochloride salt in solid form for research use. It is intended for incorporation into PROTACs and other E3 ligase recruiting conjugates for chemical biology and medicinal chemistry studies.
- Thalidomide-derived cereblon ligand for E3 ligase recruitment.
- Suitable for PROTAC construction and linker conjugation.
- Provided as a solid hydrochloride salt for stability and handling.
- Available in small milligram packages appropriate for synthesis and assays.
- Store sealed, away from moisture and light; follow supplier storage guidance.