Lactams
eMolecules 2743434-24-2 | Medchem Express | Thalidomide-5-PEG4-NH2 (hydrochloride) | 5mg | 778475789 | HY-138785A | 485.92 | C21H28ClN3O8
AstaTech | 1-(4-BROMOPHENYL)PIPERAZINE | 1g | 302795728 | 28586 | 97.000 | 66698-28-0 | MFCD00130198 | 241.132 | C10H13BrN2
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Medchemexpress LLC Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride | 2376990-30-4 | 498.91 | 50 MG
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker, and can be an immunomodulator for the treatment of cancer. PROTACs, which contain two different ligands connected by a linker (one for an E3 ubiquitin ligase and the other for the target protein), exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates an E3 ligase ligand and a linker.
- Can be an immunomodulator for the treatment of cancer.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
- For research use only.
Medchemexpress LLC Thalidomide-4-O-C6-NH2 hydrochloride | 2245697-88-3 | 98.5% | C19H24ClN3O5 | 10MG
Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate used in PROTAC research, notably as a component of the degrader dTAG-13 that directs FKBP12F36V and BET proteins for degradation. It is intended for laboratory research into E3 ligase recruitment, targeted protein degradation, apoptosis, and autophagy.
- High purity suitable for research (98.5%).
- Soluble in DMSO at 83.33 mg/mL (203.31 mM); ultrasonic assistance may be needed.
- Engages cereblon for E3 ligase-mediated protein degradation.
- Useful for PROTAC assembly and linker conjugation workflows.
- Available in small research quantities to support assay development.
- Recommended storage: 4°C sealed, away from moisture and light; in solvent, store at -80°C for long term.