Lactams
Medchemexpress LLC Thalidomide-O-C2-acid | 2369068-42-6 | 95.0% | C16H14N2O7 | 10MG
Thalidomide-O-C2-acid is an E3 ligase ligand-linker conjugate that pairs a thalidomide-derived cereblon ligand with a two-carbon linker. It is designed as a research building block for proteolysis targeting chimera (PROTAC) construction and targeted protein degradation studies, and is supplied with analytical data supporting its identity and purity.
- Contains a thalidomide-derived cereblon ligand for CRBN recruitment.
- Includes a short two-carbon linker suitable for conjugation.
- Provided with reported purity and molecular characterization.
- Available in multiple small pack sizes for research-scale synthesis.
- Intended for use as a building block in PROTAC synthesis and chemical biology studies.
- Supplied with an accessible datasheet and safety documentation.
Medchemexpress LLC Thalidomide-NH-C6-NH2 hydrochloride | 2375194-37-7 | 99.6% | 100 MG
Thalidomide-NH-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates a Thalidomide-based cereblon ligand and a linker commonly used in PROTAC technology. PROTACs are designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is intended for research use only and is not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a thalidomide-based cereblon ligand
- Features a linker used in PROTAC technology
- Designed to exploit the ubiquitin-proteasome system
- Selectively degrades target proteins
- Molecular weight: 408.88
- Chemical formula: C19H25ClN4O4
- Appearance: Light yellow to yellow solid
- Recommended storage: -20°C in sealed container, away from moisture and light
- Long-term solvent storage: 6 months at -80°C or 1 month at -20°C
Sigma Aldrich Fine Chemicals Biosciences Pomalidomide | 19171-19-8 | MFCD12756407 | 5mg
Pomalidomide | 98% (HPLC) | 273.24 | 19171-19-8 | MFCD12756407 | 5mg
Medchemexpress LLC 1H-isoindole-4-carboxylic acid, 2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo | 1547163-38-1 | MFCD32063448 | 98.0% | 302.24 g·mol-1 | C14H10N2O6 | 500 MG
Thalidomide acid is a thalidomide-derived cereblon (CRBN) ligand bearing a carboxylic acid functional group, supplied as a solid research reagent. It is intended for use as an E3 ligase recruiting moiety in PROTAC design and related chemical biology and synthetic applications.
- Ligand for E3 ligase (CRBN) used in targeted protein degradation research.
- Carboxylic acid handle enables amide coupling and linker attachment.
- High purity (98.0%) suitable for analytical and synthetic work.
- Solid powder form for convenient handling and formulation.
- Molecular weight 302.24 g·mol-1; formula C14H10N2O6.
- Identified by CAS number 1547163-38-1 for unambiguous chemical lookup.
Apexbio Technology LLC Thalidomide-O-amido-C4-NH2 TFA 1799711-25-3 50mg
Thalidomide-O-amido-C4-NH2 TFA (CAS 1799711-25-3) is a synthetic small molecule composed of a thalidomide-derived cereblon ligand conjugated to a chemical linker This compound selectively binds to cereblon (CRBN) a substrate receptor of the CRL4CRBN E3 ubiquitin ligase complex By facilitating the recruitment of target proteins to the CRBN complex it enables their ubiquitination and subsequent proteasomal degradation Thalidomide-O-amido-C4-NH2 TFA serves as a molecular tool in the development of proteolysis targeting chimeras (PROTACs) and other targeted protein degradation strategies in biomedical research
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 50 MG
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a Thalidomide-based cereblon ligand
- Uses a linker in PROTAC technology
- Targets Cereblon
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-piperazine-PEG1-NH2 diTFA | 00-00-0 | 99.4% | C25H29F6N5O9 | 10MG
Thalidomide-Piperazine-PEG1-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-based cereblon ligand with a short PEG1/piperazine linker for PROTAC design. Intended for research use only, the compound is supplied as a solid (white to yellow) with characterized solubility and storage recommendations to support experimental workflows.
- High purity for research use (99.4%).
- Thalidomide-based cereblon ligand facilitates E3 ligase recruitment.
- Short PEG1/piperazine linker suitable for PROTAC assembly.
- DMSO solubility: 100 mg/mL; sonication recommended.
- In vivo formulation options reach ~2.5 mg/mL as suspended or clear solutions.
- Storage: sealed at 4°C; in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Thalidomide-O-PEG2-propargyl | 2098487-52-4 | 98.3% | 400.38 | 500 MG
Thalidomide-O-PEG2-propargyl, also known as E3 ligase Ligand-Linker Conjugates 32, is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a 2-unit PEG linker, making it suitable for PROTAC technology. This product also functions as a click chemistry reagent, containing an Alkyne group and capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups.
- Synthesized E3 ligase ligand-linker conjugate.
- Used in PROTAC technology.
- Click chemistry reagent with an alkyne group.
- Undergoes CuAAc with azide groups.
Chemscene ChemScene | Thalidomide 5-fluoride | 5G | CS-0127616 | 0.98 | 835616-61-0| MFCD30188075 | 276.22
ChemScene | Thalidomide 5-fluoride | 5G | CS-0127616 | 0.98 | 835616-61-0| MFCD30188075 | 276.22
Chemscene ChemScene | Thalidomide-O-PEG2-propargyl | 100MG | CS-0104609 | 0.98 | 2098487-52-4| MFCD32063462 | 400.38
ChemScene | Thalidomide-O-PEG2-propargyl | 100MG | CS-0104609 | 0.98 | 2098487-52-4| MFCD32063462 | 400.38
Medchemexpress LLC Thalidomide-pyrrolidine hydrochloride | 2616553-35-4 | 98.0% | 335.74 g·mol⁻¹ | C15H14ClN3O4 | 100 MG
Thalidomide-pyrrolidine hydrochloride is an E3 ligase ligand (compound 18) used as a building block in the synthesis of PROTACs. Provided as the hydrochloride salt at research-grade purity, it is supplied in milligram-scale packages and includes storage recommendations for long-term stability.
- E3 ligase ligand suitable for PROTAC assembly.
- Hydrochloride salt form for improved handling.
- High purity: 98.0%.
- Molecular weight: 335.74 g·mol⁻¹.
- CAS number: 2616553-35-4.
- Available in multiple package sizes including 100 mg.
- Storage recommendations: in solvent -80°C for 2 years, -20°C for 1 year.
Medchemexpress LLC Thalidomide-piperazine-PEG2-NH2 diTFA | 00-00-0 | 99.7% | C27H33F6N5O10 | 10MG
Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-derived cereblon (CRBN) ligand and a PEG2-piperazine amino linker. Supplied as the bis(trifluoroacetate) salt, it is designed as a building block for assembling heterobifunctional degraders (PROTACs) to recruit CRBN and enable targeted protein degradation.
- Incorporates thalidomide-based cereblon ligand for CRBN recruitment.
- Contains a PEG2-piperazine linker with a terminal primary amine for conjugation chemistry.
- Supplied as the bis(trifluoroacetate) salt to aid handling and solubility.
- High purity suitable for synthesis (99.7%).
- Water solubility up to 50 mg/mL with ultrasonic assistance.
- Store sealed at 4°C, away from moisture.
Medchemexpress LLC Thalidomide-propargyne-PEG3-COOH | 2797649-54-6 | 96.3% | C23H24N2O9 | 10MG
Thalidomide-Propargyne-PEG3-COOH is a thalidomide-derived E3 ligase ligand-linker conjugate featuring a terminal propargyl alkyne and a PEG3 spacer terminating in a carboxylic acid. It is intended as a research reagent for chemical biology and PROTAC synthesis to enable cereblon recruitment and bioorthogonal conjugation in degradation studies.
- Provides a cereblon-binding ligand for CRBN-mediated degradation
- Contains an alkyne handle for copper-catalyzed azide-alkyne cycloaddition
- PEG3 spacer improves solubility and linker flexibility
- Terminal carboxylic acid enables amide coupling and conjugation
- Supplied at research-grade purity suitable for synthesis
Medchemexpress LLC Thalidomide-iodo | 2509137-01-1 | MFCD31735039 | >98.0% | 384.13 g/mol | C13H9IN2O4 | 1 G
Thalidomide-iodo is an iodinated thalidomide derivative that acts as an E3 ligase activator and ligand for cereblon, used in targeted protein degradation and PROTAC research. The iodine substituent enables further derivatization through cross-coupling or substitution, supporting synthesis of linker conjugates and chemical probes. Supplied as a high-purity research chemical.
Cayman Chemical AzIdo-ThalIdomIde 25mg
A PROTAC building block; contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry; has been used in the synthesis of a SirReal-based PROTAC for the degradation of Sirt2 in cells