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1

Medchemexpress LLC Thalidomide-nh-c4-nh-boc | 2093388-52-2 | 99.6% | 444.48 g/mol | C22H28N4O6 | 5 MG

Thalidomide-NH-C4-NH-Boc is a thalidomide-derived E3 ligase ligand-linker conjugate developed for PROTAC research. It combines a cereblon-binding thalidomide moiety with a Boc-protected four-carbon linker to facilitate targeted protein degradation studies. For research use only.

  • High purity: 99.64% by analytical HPLC.
  • Appropriate for PROTAC development as a cereblon ligand-linker conjugate.
  • Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
  • Storage: store at 4°C and protect from light; in solvent, -80°C (6 months) or -20°C (1 month).
  • Available in small mg quantities suitable for medicinal chemistry applications.

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2

Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | 98.0% | C25H36ClN5O9 | 10MG

Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a thalidomide-based cereblon (CRBN) ligand-linker conjugate intended as a building block for PROTAC synthesis. The molecule combines a thalidomide-derived CRBN recruiting moiety with an amino-terminated PEG4-C2 spacer to enable straightforward coupling to target ligands. It is supplied as the hydrochloride salt for improved handling and is for research use only.

  • High HPLC purity (98.0%).
  • Amino-terminated PEG4-C2 linker for facile conjugation.
  • Thalidomide-based cereblon ligand for CRBN recruitment.
  • Supplied as a solid hydrochloride salt, light yellow to yellow.
  • Available in small-scale quantities suitable for medicinal chemistry.
  • Store sealed, away from moisture; in solvent: -80°C for 6 months, -20°C for 1 month.

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3

Medchemexpress LLC VH 101 phenol-alkylC4-amine dihydrochloride | 2564467-03-2 | >95.0% | C30H44Cl2FN5O5S | 10MG

VH 101 phenol-alkylC4-amine dihydrochloride is a von Hippel-Lindau (VHL) protein ligand developed as a building block for PROTAC synthesis and E3 ligase conjugation. Supplied as the dihydrochloride salt, it is intended for research use in targeted protein degradation and conjugation workflows.

  • VHL ligand suitable for PROTAC synthesis and E3 ligase recruitment.
  • Dihydrochloride salt for improved handling and conjugation chemistry.
  • Molecular formula C30H44Cl2FN5O5S; molecular weight 676.67 g/mol.
  • Purity reported as ≥95.0% by HPLC in supplier documentation.
  • Recommended storage: keep dry at room temperature; in solvent store at -80°C (2 years) or -20°C (1 year).
  • Intended for research use in targeted protein degradation and conjugation workflows.

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