Lactones
Medchemexpress LLC Gamma-glutamylcysteine TFA | 283159-88-6 | 95.2% | 364.30 | 10 MG
Gamma-glutamylcysteine TFA is an orally active, blood-brain barrier permeable dipeptide involved in regulating macrophage polarization, inducing glutathione synthesis, and improving metabolic dysfunction. It is relevant for research in various diseases.
- Orally active and blood-brain barrier permeable dipeptide.
- Activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, IGF-1R/IRS1/PI3K, and Nrf2 signaling pathways.
- Inhibits NF-κB, JAK1/STAT1/3, MAPKs, and PI3K/Akt signaling pathways.
- Regulates macrophage polarization and modulates CD36 and GLUT4 trafficking.
- Induces glutathione synthesis, improves metabolic dysfunction, and ameliorates glucose homeostasis.
- Reduces lipid deposition, inhibits apoptosis, stabilizes mitochondria, and suppresses ferroptosis.
- Relevant for research in inflammatory bowel disease, type 2 diabetes, Alzheimer's disease, and alcoholic liver disease.
Medchemexpress LLC Fc gamma RIIB/CD32b 10ug | 10ug
Fc RIIB/CD32b proteins exhibit low affinity as complexes or receptors that aggregate the immunoglobulin Fc region ITIM phosphorylated by Fc RIIB/CD32b recruits inositol phosphatases SHIP1 and SHIP2 inhibits Ras activation down-regulates MAPK activity reduces PLC- function and results in PKC activation Inhibition of MAP kinase pathway and anti-apoptotic kinase Akt inhibit cell proliferation and survival Fc gamma RIIB/CD32b Protein Cynomolgus (HEK293 His) is the recombinant cynomolgus-derived Fc gamma RIIB/CD32b protein expressed by HEK293 with C-His labeled tag
Medchemexpress LLC AMPK gamma 1/beta 2/alpha 2 heterotrimer protein, human (Sf9, His-GST) | >90.0% | 50 UG
Recombinant human AMPK heterotrimer (α2, β2, γ1) expressed in Sf9 insect cells, supplied as a filtered solution with N-terminal His and GST tags for biochemical and structural studies. The preparation is formulated in a stabilizing buffer and provided for research use only.
- Source organism: human.
- Expression system: Sf9 insect cells.
- Tags: N-terminal His and GST.
- Purity: >90.0% by reducing SDS-PAGE.
- Formulation: filtered solution in 50 mM Tris, 200 mM NaCl, 1 mM EDTA, 1 mM DTT, 10% glycerol, pH 7.4.
- Storage: store at -80 °C for long-term and avoid repeated freeze-thaw cycles.
- Intended use: for research use only.
Medchemexpress LLC L-Cysteine, L-γ-glutamyl-, 2,2,2-trifluoroacetate (1:1) | 283159-88-6 | 95.2% | 364.30 | 1 ML
Gamma-glutamylcysteine TFA (γ-Glutamylcysteine TFA) is an orally active, blood-brain barrier permeable dipeptide. It activates various signaling pathways like AMPK and Nrf2, while inhibiting others such as NF-κB and MAPKs. This compound regulates macrophage polarization, induces glutathione synthesis, improves metabolic dysfunction, and alleviates hepatic lipid droplet formation.
- Applicable to research related to inflammatory bowel disease.
- Applicable to research related to type 2 diabetes.
- Applicable to research related to cadmium-induced neurotoxicity.
- Applicable to research related to Alzheimer's disease.
- Applicable to research related to cerebral ischemia/reperfusion injury.
- Applicable to research related to neuropathy.
- Applicable to research related to alcoholic liver disease.
eMolecules 174180-53-1 | TERT-BUTYL 2-(HYDROXYMETHYL)-1H-INDOLE-1-CARBOXYLATE | AstaTech | MFCD09032312 | 247.294 | C14H17NO3 | 95.000 | CC(C)(C)OC(=O)n1c(CO)cc2ccccc12 | 0.25g | 261441238
TERT-BUTYL 2-(HYDROXYMETHYL)-1H-INDOLE-1-CARBOXYLATE | AstaTech | 174180-53-1 | MFCD09032312 | 247.294 | C14H17NO3 | 95.000 | CC(C)(C)OC(=O)n1c(CO)cc2ccccc12 | 0.25g | 261441238
eMolecules 110928-44-4 | trans-Methyl 4-(hydroxymethyl)cyclohexanecarboxylate | MFCD03840884 | 1g
Ambeed | 25-Bis(2-ethylhexyl)-36-di(thiophen-2-yl)pyrrolo[34-c]pyrrole-14(2H5H)-dione | 100mg | 552742515 | A549490 | 1185885-86-2 | MFCD22200076 | 524.780 | C30H40N2O2S2
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eMolecules 914349-11-4 | 1-Boc-5-cyano-3-hydroxymethylindole | Combi-Blocks | MFCD05864719 | 272.304 | C15H16N2O3 | 96.000 | CC(C)(C)OC(=O)n1cc(CO)c2cc(ccc12)C#N | 1g | 482935716
1-Boc-5-cyano-3-hydroxymethylindole | Combi-Blocks | 914349-11-4 | MFCD05864719 | 272.304 | C15H16N2O3 | 96.000 | CC(C)(C)OC(=O)n1cc(CO)c2cc(ccc12)C#N | 1g | 482935716
eMolecules 74020-82-9 | 3-Hydroxy-4-(hydroxymethyl)benzoic acid | 250mg
Ambeed | 3-Hydroxy-4-(hydroxymethyl)benzoic acid | 250mg | 600836669 | A293643 | 74020-82-9 | 168.148 | C8H8O4
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Medchemexpress LLC Gamma catenin antibody (YA3801) | 82 kDa | 50 UL
This gamma Catenin Antibody (YA3801) is a mouse-derived, non-conjugated IgG1 monoclonal antibody targeting gamma Catenin. It is affinity purified and supplied in PBS with 0.05% sodium azide. Gamma catenin is a common junctional plaque protein that plays a key role in cytoskeletal organization and cellular function within tissues, influencing the structure and function of submembranous plaques.
- Suitable for research applications
- Reacts with human samples
- Predicted and observed molecular weight is 82 kDa
- Applications include WB, IHC-P, ICC/IF, and ELISA
- Stored at -20°C for 1 year
- Avoid repeated freeze/thaw cycles
Medchemexpress LLC IFN-gamma Mouse HE 10ug
IFN-gamma is a type II interferon family cytokine that participates in antiviral antibacterial and antitumor responses IFN-gamma Protein Mouse (HEK293 Fc) is the recombinant mouse-derived IFN-gamma protein expressed by HEK293 with C-hFc labeled tag
Medchemexpress LLC IFN-gamma R1/CD119 500ug
IFN-gamma R1 (CD119) one of the subunit of IFN-gamma receptor is a receptor for IFN-gamma IFN-gamma R1 forms the functional receptor with IFN-gamma R2 Upon binding with IFN-gamma IFN-gamma R1 and IFN-gamma R2 oligomerize and transphosphorylate[1] Then JAK1 and JAK2 are phosphorylated and activated and STAT1 is recruited to the receptor complex Phosphorylated STAT1 translocates to the nucleus where it regulates the expression of IFN-responsive genes (e g CD54)[2] IFN-gamma R1/CD119 Protein Mouse (HEK293 His) is a recombinant mouse IFN-gamma R1 with C-terminal 6 His tag which is produced in HEK293 cells
eMolecules tert-Butyl ((1-(hydroxymethyl)cyclopropyl)methyl)carbamate | 153248-46-5 | MFCD09031543 | 1g
Combi-Blocks | tert-Butyl ((1-(hydroxymethyl)cyclopropyl)methyl)carbamate | 1g | 267177321 | QC-1910 | 97.000 | 153248-46-5 | MFCD09031543 | 201.266 | C10H19NO3
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Medchemexpress LLC Interleukin-36 gamma (IL-1F9) | >95.0% | 2UG
Recombinant, animal-free mouse interleukin-36 gamma (IL-1F9) expressed in E. coli with a C-terminal 6xHis tag. It activates NF-κB signaling via IL1RL2 and promotes inflammatory responses in epithelial tissues by influencing keratinocytes, dendritic cells, and T cells. Supplied lyophilized for research use in cell culture.
- High purity (>95%) as determined by reducing SDS-PAGE.
- Predicted molecular mass 18.3 kDa; ~17 kDa on SDS-PAGE.
- Contains sequence corresponding to G13-S164 of mouse IL-36γ.
- Lyophilized formulation in PBS (pH 7.4) with trehalose for stability.
- Reconstitute to 100-200 μg/mL in ddH2O for typical use.
- Stable frozen at -20 °C for up to 2 years; aliquot for long-term storage.
- Intended for cell culture research use only.