Oxazinanes
Medchemexpress LLC Prexasertib (dihydrochloride) | 1234015-54-3 | 99.7% | 438.31 | 50 MG
Prexasertib dihydrochloride is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with potent anti-tumor activity. It causes double-stranded DNA breakage and replication catastrophe, leading to apoptosis.
- Selective CHK1 inhibitor with Ki of 0.9 nM and IC50 of <1 nM
- Also inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM)
- Causes double-stranded DNA breakage
- Induces replication catastrophe and apoptosis
- Demonstrates potent anti-tumor activity
- Inhibits MELK (IC50=38 nM), SIK (IC50=42 nM), BRSK2 (IC50=48 nM), and ARK5 (IC50=64 nM)
- Requires CDC25A and CDK2 to induce DNA damage
- Causes chromosomal fragmentation in HeLa cells
- Induces replication stress and depletes RPA2 available for DNA binding
- Shows tumor growth inhibition in xenografts
Cayman Chemical MethylLNIO hydrochloride
A competitive NOS inhibitor; more potent inhibitor of nNOS (Ki = 3.0 µM) than eNOS (Ki = 10.0 µM) or iNOS (Ki = 9.5 µM)
Medchemexpress LLC Cyclopent[b]indol-1(2H)-one, 3,4-dihydro-4-methyl- | 50776-26-6 | 99.9% | C12H11NO | 500 MG
4-Methyl-2,3-dihydrocyclopenta[b]indol-1(4H)-one, also identified as Cyclopent[b]indol-1(2H)-one, 3,4-dihydro-4-methyl-, is a chemical compound primarily used as a drug intermediate. It is critical for the synthesis of various active compounds in research settings.
- Used as a drug intermediate for synthesis
- Intended for research use only
- Not fully validated for medical applications
- Exhibits a purity of 99.94%
- Molecular formula is C12H11NO
- Molecular weight is 185.23
Medchemexpress LLC 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid | 956317-36-5 | 99.99% | C10H9N3O2 | 10 G
5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid is a chemical compound used as a laboratory reagent and in the manufacture of other substances. This white to off-white solid is characterized by its high purity and specific storage requirements.
- High purity (99.99%)
- Suitable for laboratory chemicals and manufacture of other substances
- Stable as powder at -20°C for 3 years or 4°C for 2 years
- In solvent, stable at -80°C for 6 months or -20°C for 1 month
- Appears as a white to off-white solid
Medchemexpress LLC Prexasertib (dihydrochloride) | 1234015-54-3 | 99.4% | 438.31 | 25 MG
Prexasertib (dihydrochloride) | 1234015-54-3 | 99.4% | 438.31 | 25 MG
Medchemexpress LLC S1ra (hydrochloride) | 1265917-14-3 | 99.9% | 373.88 | 250 MG
S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. It demonstrates good selectivity against σ2R (Ki >1000 nM). This compound is also identified as a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride has been shown to inhibit neuropathic pain and activity-induced spinal sensitization.
- Orally active and selective sigma-1 receptor (σ1R) antagonist
- High affinity for human and guinea pig σ1Rs
- Good selectivity against sigma-2 receptors (σ2R)
- Acts as a human 5-HT2B receptor antagonist
- Inhibits neuropathic pain
- Reduces activity-induced spinal sensitization
- Demonstrates analgesic effects on formalin-evoked nociceptive behaviors in mice
- Reverses capsaicin-induced mechanical hypersensitivity in mice
eMolecules 4-(Morpholin-4-yl)-2-(trifluoromethyl)aniline | 78335-26-9 | MFCD01436021 | 1g
Combi-Blocks, Inc. | 4-(Morpholin-4-yl)-2-(trifluoromethyl)aniline | 1g | 603132120 | QG-9976 | 95.000 | 78335-26-9 | MFCD01436021 | 246.233 | C11H13F3N2O
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Medchemexpress LLC 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, hydrochloride (1:2), (6S)- | 104632-25-9 | 99.7% | 284.25 | 50 MG
Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist. It has Ki values of 2.2 nM for the D2-type receptor, 3.9 nM for D2, 0.5 nM for D3, and 1.3 nM for D4 receptors. It is used in the research of Parkinson's disease (PD) and restless legs syndrome (RLS).
- Selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist
- Can be used for research of Parkinson's disease (PD)
- Can be used for research of restless legs syndrome (RLS)
Medchemexpress LLC (6S,12aR)-Tadalafil (Tadalafil EP Impurity C) | 171596-28-4 | 99.5% | C22H19N3O4 | 50 MG
(6S,12aR)-Tadalafil (Tadalafil EP Impurity C) is a highly potent PDE5 inhibitor with an IC50 value of 5 nM and has blood pressure lowering activity. It is intended for research use only and is not sold to patients.
- Highly potent PDE5 inhibitor with an IC50 value of 5 nM.
- Has blood pressure lowering activity.
- Suitable for research applications only.
eMolecules ChemScene / tert-Butyl (morpholin-3-ylmethyl)carbamate / 100mg / 569144491 / CS-0054197 / 0.000 / 169750-75-8 / MFCD11111574 / 216.281 / C10H20N2O3
ChemScene / tert-Butyl (morpholin-3-ylmethyl)carbamate / 100mg / 569144491 / CS-0054197 / 0.000 / 169750-75-8 / MFCD11111574 / 216.281 / C10H20N2O3