Oxazinanes

Organic heterocyclic compounds that consist of a six-membered ring that has four carbon atoms, one nitrogen atom, and one oxygen atom.

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1,711 – 1,725 of 2,960 results

1,711

Apexbio Technology LLC MPC 6827 hydrochloride 917369-31-4 10mM (in 1mL DMSO)

MPC 6827 hydrochloride (CAS 917369-31-4) also known as Azixa is a small-molecule microtubule destabilizer that binds to the colchicine site on -tubulin By disrupting microtubule dynamics it induces mitotic arrest at the G2-M phase resulting in apoptotic cell death In preclinical models MPC 6827 has suppressed the growth of various subcutaneously implanted tumor cell lines and demonstrated vascular disruptive activity in human ovarian cancer xenografts Additionally it has shown synergy with carboplatin and inhibited glioblastoma growth in intracranial xenograft models MPC 6827 is utilized in cancer research to elucidate microtubule-targeting mechanisms and investigate tumor biology

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1,712

Apexbio Technology LLC Aliskiren Hemifumarate 173334-58-2 10mM (in 1mL DMSO)

Aliskiren Hemifumarate (CAS 173334-58-2) is a small molecule classified as a direct renin inhibitor By binding to renin it blocks the initial step in the renin-angiotensin-aldosterone system (RAAS) thereby reducing the conversion of angiotensinogen to angiotensin I and lowering downstream angiotensin II levels This mechanism results in decreased vasoconstriction and aldosterone-mediated sodium retention Aliskiren Hemifumarate is primarily studied in the context of essential hypertension and serves as a tool compound for exploring renin-dependent regulatory pathways and therapeutic strategies targeting blood pressure homeostasis

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1,713

eMolecules S S-BN-PYBOX 10G

5000158876 S S-BN-PYBOX 10G

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1,714

Apexbio Technology LLC Amsacrine hydrochloride 54301-15-4 10mM (in 1mL DMSO)

Amsacrine hydrochloride (CAS 54301-15-4) also known as m-AMSA is a small molecule inhibitor of DNA topoisomerase II By interfering with the religation step of the topoisomerase II catalytic cycle it induces DNA strand breaks and disrupts DNA replication and transcription In vitro studies have shown that Amsacrine hydrochloride exhibits cytotoxicity against various cancer cell lines including bladder (HT1376 RT112 RT4) and testicular (833K Susa GH) cancer cells with IC50 values ranging from 5 0 to 190 2 ng/ml Testicular cancer cell lines display greater sensitivity to this agent compared to bladder cancer cell lines Amsacrine hydrochloride is utilized in research exploring DNA damage mechanisms and antineoplastic drug responses

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1,715

eMolecules 1818847-43-6 | 1-Methylazetidin-3-one hydrochloride | Combi-Blocks, Inc. | MFCD29060167 | 121.560 | C4H8ClNO | 95.000 | Cl.CN1CC(=O)C1 | 250mg | 603148394

1-Methylazetidin-3-one hydrochloride | Combi-Blocks, Inc. | 1818847-43-6 | MFCD29060167 | 121.560 | C4H8ClNO | 95.000 | Cl.CN1CC(=O)C1 | 250mg | 603148394

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1,716

eMolecules 6-BROMO-3 4-DIHYDRO-2H-ISO 25G

5000165136 6-BROMO-3 4-DIHYDRO-2H-ISO 25G

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1,717

eMolecules 1225376-02-2 | (R)-2-Phenylmorpholine | J & W PharmLab LLC | MFCD18249849 | 163.220 | C10H13NO | 96.000 | C1CO[C@@H](CN1)c1ccccc1 | 100mg | 517669113

(R)-2-Phenylmorpholine | J & W PharmLab LLC | 1225376-02-2 | MFCD18249849 | 163.220 | C10H13NO | 96.000 | C1CO[C@@H](CN1)c1ccccc1 | 100mg | 517669113

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1,718

eMolecules EMOLECULES INC

5000191364 MORPHOLIN-2-ONE 100MG

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1,719

eMolecules 1185-53-1 | THAM (hydrochloride) | ChemScene | MFCD00012590 | 157.590 | C4H12ClNO3 | 97.000 | Cl.NC(CO)(CO)CO | 500g | 572236905

THAM (hydrochloride) | ChemScene | 1185-53-1 | MFCD00012590 | 157.590 | C4H12ClNO3 | 97.000 | Cl.NC(CO)(CO)CO | 500g | 572236905

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1,720

Apexbio Technology LLC Xamoterol hemifumarate 73210-73-8 5mg

Xamoterol hemifumarate (CAS 73210-73-8) is a selective 1-adrenergic receptor agonist targeting cardiac 1 receptors It is designed to activate 1-adrenergic signaling pathways thereby modulating myocardial function and cardiac electrophysiological processes Xamoterol hemifumarate exerts its biological activity primarily through 1-adrenergic receptor stimulation influencing downstream intracellular signaling cascades related to cardiac rhythm regulation In experimental settings it is utilized in vitro with cellular cardiac models and in vivo with animal models to assess 1-adrenergic receptor-mediated effects particularly in the interaction with cardiac ion channels such as the rapid delayed rectifier potassium current (IKr) Based on these pharmacological properties Xamoterol hemifumarate holds research potential in the study of arrhythmogenesis mechanisms and cardiac electrophysiology