Oxazinanes
Cayman Chemical PropenylLNIO hydrochloride
A potent, selective iNOS inhibitor (Kis = 17, 10.3 and 58.2 µM for iNOS, nNOS, and eNOS, respectively, for initial rate binding kinetics); demonstrates reversible tight binding inhibition that is selective for iNOS over nNOS (Kis = 0.56 and 6 µM, respectively)
Cayman Chemical O2545 hydrochloride
A potent water-soluble agonist of CB1 and CB2 receptors with Ki values of 1.5 and 0.32 nM, respectively; when dissolved in saline, is highly efficacious in mouse behavioral models when administered either intravenously or intracerebroventricularly
Cayman Chemical EthylLNIO hydrochloride
A modestly selective NOS inhibitor with Ki values for inhibition of nNOS, eNOS, and iNOS of 5.3, 18, and 12 µM, respectively; however, does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively)
Cayman Chemical HA1077 hydrochloride
A potent inhibitor of ROCK2, PRK-2, MSK1, and MAPKAP-K1b with IC50 values of 1.9, 4, 5, and 15 µM, respectively; has been shown to reduce blood vessel constriction, decreases pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in a diabetic rat model; drug forms are marketed for the treatment of pulmonary arterial hypertension and stable angina
Cayman Chemical SH1152 hydrochloride
A potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK (Ki = 1.6 nM); more potent inhibitor of ROCK than either Y-27632 (Ki = 140 nM) or HA-1077 (Ki = 330 nM); poorly inhibits PKA, PKC, and MLCK
Cayman Chemical SB242084 hydrochloride
An antagonist of the 5-HT2C receptor (pKi = 9.0), with at least 100-fold more selectivity over other 5-HT, dopamine, or adrenergic receptors; brain penetrant with significant anxiolytic activity; used extensively in animal research
Sigma Aldrich Fine Chemicals Biosciences Adrenalone hydrochloride U25MG
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
AdipoGen GW311616A hydrochloride
Chemical. CAS 197890-44-1. Formula C19H31N3O4S . HCl. MW 397.5 . 36.5. Potent, selective intracellular neutrophil elastase NE, alpha-1-proteinase inhibitor by covalently binding to NE. Inhibits human neutrophil elastase HNE and is selective over other human serine proteases with IC50 values of 22nM for HNE, >100µM for trypsin, cathepsin G and plasmin, >3µM for chymotrypsin and tissue plasminogen activator. Specific beta-cell proliferation promoter. Similar to SerpinB1, which functions through its inhibiting activity of several proteases including neutrophil elastase, cathepsin G and proteinase-3. Reverses insulin resistance and body weight gain in HFD-fed mice, suggesting that the SerpinA1-NE system regulates AMPK signaling, fatty acid oxidation FAO and energy expenditure. The imbalance between SerpinA1 alpha1-antitrypsin A1AT and neutrophil elastase NE contributes to the development of obesity and related inflammation, insulin resistance and liver steatosis.
Sigma Aldrich Fine Chemicals Biosciences Butan 3 one 2 yl butanoate5KG
Butan 3 one 2 yl butanoate5KG
Cayman Chemical SH1152 hydrochloride
A potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK (Ki = 1.6 nM); more potent inhibitor of ROCK than either Y-27632 (Ki = 140 nM) or HA-1077 (Ki = 330 nM); poorly inhibits PKA, PKC, and MLCK
Sigma Aldrich Fine Chemicals Biosciences Leupeptin hydrochloride mi25MG
Leupeptin hydrochloride mi25MG
Cayman Chemical MethylLNIO hydrochloride
A competitive NOS inhibitor; more potent inhibitor of nNOS (Ki = 3.0 µM) than eNOS (Ki = 10.0 µM) or iNOS (Ki = 9.5 µM)
Cayman Chemical SKF 96365 hydrochloride
Inhibits the receptor-mediated influx of calcium via voltage-gated calcium channels (IC50 = 10 µM); inhibits the acetylcholine-induced depolarization of circular smooth muscle in a dose-dependent manner at 3-50 µM
Cayman Chemical SH1152 hydrochloride
A potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK (Ki = 1.6 nM); more potent inhibitor of ROCK than either Y-27632 (Ki = 140 nM) or HA-1077 (Ki = 330 nM); poorly inhibits PKA, PKC, and MLCK
Sigma Aldrich Fine Chemicals Biosciences Bestatin hydrochloride 9825MG
Chemical structure amino acid derivatives