Oxazinanes
Sigma Aldrich Fine Chemicals Biosciences Bestatin hydrochloride 9825MG
Chemical structure amino acid derivatives
Sigma Aldrich Fine Chemicals Biosciences Adrenalone hydrochloride P50MG
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Medchemexpress LLC Thz1 (hydrochloride) | 99.1% | C31H29Cl2N7O2 | 10MM/1ML
THZ1 Hydrochloride is a selective and potent covalent inhibitor of CDK7, with an IC50 of 3.2 nM. It also inhibits the closely related kinases CDK12 and CDK13, leading to the downregulation of MYC expression.
- Functions as a selective and potent covalent CDK7 inhibitor.
- Inhibits closely related kinases, specifically CDK12 and CDK13.
- Downregulates MYC expression.
Cayman Chemical O2545 hydrochloride
A potent water-soluble agonist of CB1 and CB2 receptors with Ki values of 1.5 and 0.32 nM, respectively; when dissolved in saline, is highly efficacious in mouse behavioral models when administered either intravenously or intracerebroventricularly
Cayman Chemical Nefazodone hydrochloride
A serotonin, norepinephrine, and dopamine reuptake inhibitor (Kis = 137, 570, 2,380 nM, respectively); an antagonist of 5-HT2A, 5-HT1A, and histamine H1 receptors, as well as α1- and α2-ARs (Kis = 7.1, 52, 30, 5.5, and 84 nM, respectively); reduces immobility time in the tail suspension test in gerbils at 100 mg/kg; toxic to isolated human hepatocytes in a cultured sandwich hepatocyte preparation at 30 µM
AdipoGen GW311616A hydrochloride
Chemical. CAS 197890-44-1. Formula C19H31N3O4S . HCl. MW 397.5 . 36.5. Potent, selective intracellular neutrophil elastase NE, alpha-1-proteinase inhibitor by covalently binding to NE. Inhibits human neutrophil elastase HNE and is selective over other human serine proteases with IC50 values of 22nM for HNE, >100µM for trypsin, cathepsin G and plasmin, >3µM for chymotrypsin and tissue plasminogen activator. Specific beta-cell proliferation promoter. Similar to SerpinB1, which functions through its inhibiting activity of several proteases including neutrophil elastase, cathepsin G and proteinase-3. Reverses insulin resistance and body weight gain in HFD-fed mice, suggesting that the SerpinA1-NE system regulates AMPK signaling, fatty acid oxidation FAO and energy expenditure. The imbalance between SerpinA1 alpha1-antitrypsin A1AT and neutrophil elastase NE contributes to the development of obesity and related inflammation, insulin resistance and liver steatosis.
Medchemexpress LLC CN128 hydrochloride | 1335282-05-7 | 98.2% | 10 MM 1 ML
CN128 hydrochloride is an orally active and selective iron chelator. It is used for the research of β-thalassemia.
- Orally active and selective iron chelator
- High selectivity for iron(III) over other metals
- Lacks genetic toxicity and is well-tolerated
- Exhibits good oral bioavailability
- Demonstrates good iron scavenging efficacy in rats
- Iron removal efficacies are dose-dependent
Sigma Aldrich Fine Chemicals Biosciences TrizmaR hydrochloride reag25KG
Trizma(R) hydrochloride is mainly required for preparation of buffer at physiological range of 7.3 to 7.5. The prepared buffer is compatible with biological fluids. It is of importance to laboratories as a standard pH SOLUTIONon.
Cayman Chemical SKF 96365 hydrochloride
Inhibits the receptor-mediated influx of calcium via voltage-gated calcium channels (IC50 = 10 µM); inhibits the acetylcholine-induced depolarization of circular smooth muscle in a dose-dependent manner at 3-50 µM
Cayman Chemical Y27632 hydrochloride
A potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM); also inhibits PRK2 with an IC50 value of 600 nM
Medchemexpress LLC Prexasertib (dihydrochloride) | 1234015-54-3 | 99.4% | 438.31 | 1 ML
Prexasertib dihydrochloride is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. It causes double-stranded DNA breakage and replication catastrophe, leading to apoptosis, and exhibits potent anti-tumor activity. It also inhibits CHK2 and RSK1.
- Selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor.
- Causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis.
- Shows potent anti-tumor activity.
- Inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM).
TARGETMOL CHEMICALS INC VARDENAFIL HYDROCHLORIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Vardenafil hydrochloride trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1 respectively. purity: 99%
TARGETMOL CHEMICALS INC IDARUBICIN HYDROCHLORIDE 25MG
Also available in 5 mg 10 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Idarubicin hydrochloride (Zavedos) a hydrochloride salt form of Idarubicin is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50 3.3 ng/mL). purity: 99%
TARGETMOL CHEMICALS INC SCH-23390 HYDROCHLORIDE 25MG
Also available in 1 mg 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist and for the D1(Ki=0.2 nM) and D5(Ki=0.3 nM). purity: 99%
Cayman Chemical RIluzolehydrochlorIde 50mg
A benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM); suppresses glutamate-induced seizures in rats (ED50 = 3.2 mg/kg) and displays neuroprotective effects in hypoxic animals (ED50 = 4 mg/kg)