Oxazinanes
Aobchem 1-Methyl-2-(2-nitrophenoxy)benzene | ≥97% | CAS 54106-40-0 | C13H11NO3 | 5g
1-Methyl-2-(2-nitrophenoxy)benzene | ≥97% | CAS 54106-40-0 | C13H11NO3 | 5g
Aobchem 3-Chloro-6-(2 3-dihydro-1 4-benzodioxin-6-yl)pyridazine | ≥95% | CAS 878710-85-1 | C12H9ClN2O2 | 1g
3-Chloro-6-(2 3-dihydro-1 4-benzodioxin-6-yl)pyridazine | ≥95% | CAS 878710-85-1 | C12H9ClN2O2 | 1g
Matrix Scientific 3,4-DIHYDRO-2H-1,4-BENZOXAZ-1G
3,4-Dihydro-2H-1,4-benzoxazine, 1g,C8H9NO, MFCD02181098, mw 135.17, [5735-53-5]
Cayman Chemical Pargyline (hydrochloride), Purity: ≥98%, CAS: 306-07-0, 500 mg
An irreversible inhibitor of MAO (Kis = 15 and 1.8 μM for MAO-A and MAO-B, respectively); induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Dawley rats; prevents reactive oxygen species-mediated monocyte hypertrophy at a concentration of 10 µM
Cayman Chemical Trimidox (hydrochloride), Purity: ≥98%, CAS: 95933-75-8, 25 mg
A specific ribonucleotide reductase inhibitor; inhibits growth of human promyelocytic leukemia HL-60 cells (IC50 = 35 µM)
Aobchem 5 8-Dibromo-2 3-dihydro-1 4-benzodioxin | 97% | CAS 2385024-17-7 | C8H6Br2O2 | 250mg
5 8-Dibromo-2 3-dihydro-1 4-benzodioxin | 97% | CAS 2385024-17-7 | C8H6Br2O2 | 250mg
Cayman Chemical Methyl-L-NIO (hydrochloride), Purity: ≥98%, CAS: 150403-96-6, 5 mg
A competitive NOS inhibitor; more potent inhibitor of nNOS (Ki = 3.0 µM) than eNOS (Ki = 10.0 µM) or iNOS (Ki = 9.5 µM)
Cayman Chemical GW 3965 (hydrochloride), Purity: ≥98%, CAS: 405911-17-3, 5 mg
An orally-active agonist of LXRα and LXRβ, activating the human isoforms with EC50 values of 190 and 30 nM, respectively; alters LXR-regulated gene expression in mice and rats, affecting pathways related to glucose and lipid metabolism
Cayman Chemical Ethyl-L-NIO (hydrochloride), Purity: ≥95%, CAS: 150403-97-7, 100 mg
A modestly selective NOS inhibitor with Ki values for inhibition of nNOS, eNOS, and iNOS of 5.3, 18, and 12 µM, respectively; however, does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively)
SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES TRIPROLIDINE HYDROCHLORIDE 1G
NC3373054 TRIPROLIDINE HYDROCHLORIDE 1G
Cayman Chemical Dimebolin (hydrochloride), Purity: ≥98%, CAS: 97657-92-6, 25 mg
A neuroprotective agent; binds to histamine H1 and H2 receptors (IC50s = 3.8 and 287 nM, respectively), as well as α1A-, α1B-, α1D-, and α2A-ARs, imidazoline I2 receptors, and 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 receptors (Kis = 8-313 nM); inhibits NMDA-evoked currents and voltage-gated calcium channels in mouse primary striatal neurons (IC50s = 10 and 50 μM, respectively); inhibits glutamate-induced apoptosis in primary striatal neurons derived from the YAC128 transgenic mouse model of Huntington’s disease at 50 μM; inhibits cell death induced by amyloid-β (25-35) in cerebellar granule cells at 25 μM; inhibits decreases TWAA acquisition in a rat model of AF64A-induced Alzheimer’s disease at 1 mg/kg
Cayman Chemical DL-threo-PDMP (hydrochloride), Purity: ≥98%, CAS: 80938-69-8, 50 mg
An inhibitor of sphingolipid biosynthesis; inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates at 5 and 10 µM; reduces the synthesis of glucosylceramide increases cellular ceramide, and induces cell cycle arrest; increases Aβ42 and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity